2. NF-κB
  3. NF-κB
  4. NF-κB-IN-8

NF-κB-IN-8 竞争性拮抗 LPS 与 MD-2 的结合。NF-κB-IN-8 通过与 MD-2 结合来降低炎症因子的表达。NF-κB-IN-8 也抑制 ALP 活性。NF-κB-IN-8 可用于急性肺损伤 (ALI) 等炎症疾病的研究。

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NF-κB-IN-8 Chemical Structure

NF-κB-IN-8 Chemical Structure

CAS No. : 2924565-59-1

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NF-κB-IN-8 相关抗体

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI)[1].

体外研究
(In Vitro)

NF-κB-IN-8 (化合物 L26) (10 μM) 抑制 64.30% 的 ALP 活性[1]。
NF-κB-IN-8 (1-10 μM, 24 h) 抑制 RAW 264.7 细胞中 IL-6 和 TNF-α 的表达[1]。
NF-κB-IN-8 (0-50 μM) 抑制 LPS 与 MD-2 的结合，通过 ELISA 检测[1]。
NF-κB-IN-8 (50 μM，过夜) 抑制 RAW264.7 细胞中 LPS/MD-2/TLR4 聚合物的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-8 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Inhibited the expression of LPS/MD-2/TLR4 polymers.
体内研究
(In Vivo)

NF-κB-IN-8 (化合物 L26) (5 mg/kg，灌胃给药) 减轻 LPS 诱导的小鼠急性肺损伤[1]。
NF-κB-IN-8 (1000 和 1500 mg/kg，灌胃给药) 对小鼠毒性低，且安全[1]。
NF-κB-IN-8 (0 mg/kg, 大鼠) 显示出 T1/2: 4.2 h, Cmax: 163.288 μg/L[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ALI mice induced by LPS[1]
Dosage: 5 mg/kg
Administration: Intra-gastrically administration
Result: Downregulated the expression of pro-inflammatory factor Mrna (TNF-α).
Decreased ALP level in bronchoalveolar lavage fluid.
Inhibited the phosphorylation of p65 and increased the release of IκB-α. (WB assay, lung tissue sample)
分子量

399.44

Formula

C24H21N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-82924565-59-1NF-κBNuclear factor-κBNuclear factor-kappaBCancerALIacute lung injuryALPLPSInhibitorinhibitorinhibit

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