NG-nitro-L-arginine (Synonyms: Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine)

目录号: HY-12115 纯度: 99.78%: Data Sheet SDS COA 产品使用指南
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NG-nitro-L-arginine (Nω-nitro-L-arginine) 是一种 NO Synthase 抑制剂，其 Ki 分别为 0.61 μM (nNOS)、4.28 μM (iNOS)、0.72 μM (eNOS)。NG-nitro-L-arginine 可抑制内皮源性舒张因子 (EDRF) 的形成和释放。NG-nitro-L-arginine 可抑制门脉高压大鼠的门脉体循环。NG-nitro-L-arginine 可以升高血压。

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NG-nitro-L-arginine Chemical Structure

CAS No. : 2149-70-4

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50 g	￥320	In-stock
100 g	￥512	In-stock
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nNOS iNOS eNOS

生物活性
纯度 & 产品资料
参考文献

生物活性

NG-nitro-L-arginine (Nω-nitro-L-arginine) is a NO Synthase inhibitor, with K_is of 0.61 μM (nNOS), 4.28 μM (iNOS), 0.72 μM (eNOS) respectively. NG-nitro-L-arginine inhibits endothelium-derived relaxing factor (EDRF) formation and release. NG-nitro-L-arginine inhibits portal-systemic shunting in portal-hypertensive rats, and increases blood pressure^[1]^[2]^[3]^[4].

IC₅₀ & Target

K_is: 0.61 μM (nNOS), 4.28 μM (iNOS), 0.72 μM (eNOS)^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	5 μM Compound: L-NNA	Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assay Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assay	[PMID: 22370337]
RAW	IC₅₀	14 μM Compound: 1	Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cells	[PMID: 9651169]
RAW264.7	CC₅₀	> 100 μM Compound: Nomega-nitro-L-arginine	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay	[PMID: 22148193]
RAW264.7	IC₅₀	143.55 μM Compound: Nomega-nitro-L-arginine	Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method	[PMID: 22148193]
RAW264.7	IC₅₀	144.3 μM Compound: N-Omega-nitro-L-arginine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay	[PMID: 27976895]
RAW264.7	IC₅₀	146.4 μM Compound: L-NNA	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis	[PMID: 24597849]
RAW264.7	IC₅₀	152.46 μM Compound: N-omega-nitro-L-arginine	Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 21846089]
RAW264.7	IC₅₀	2.918 μM Compound: L-NNA	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA	[PMID: 33065432]
RAW264.7	IC₅₀	37.7 μM Compound: L-NA	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method	[PMID: 28561586]
RAW264.7	IC₅₀	39.5 μM Compound: N-nitro-L-arginine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based spectrophotometrical method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based spectrophotometrical method	[PMID: 33422907]
RAW264.7	IC₅₀	43.6 μM Compound: L-NA	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent method	[PMID: 19715321]

Clinical Trial

分子量

219.20

Formula

C₆H₁₃N₅O₄

CAS 号

2149-70-4

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

H₂O 中的溶解度 : 3.33 mg/mL (15.19 mM; 超声助溶; 酸性条件溶解 (HCl 调节，pH≈2))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5620 mL	22.8102 mL	45.6204 mL
5 mM	0.9124 mL	4.5620 mL	9.1241 mL
10 mM	0.4562 mL	2.2810 mL	4.5620 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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浓度 _(final)

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动物溶解方案计算器

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您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.78%

选择批次：

Data Sheet (596 KB) SDS (604 KB)

COA (281 KB) HNMR (251 KB) LCMS (89 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Seo J, et al. Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. J Med Chem. 2007 May 3;50(9):2089-99. [Content Brief]

[2]. Ishii K, et al. N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation. Eur J Pharmacol. 1990 Feb 6;176(2):219-23. [Content Brief]

[3]. Lee FY, et al. Administration of N omega-nitro-L-arginine ameliorates portal-systemic shunting in portal-hypertensive rats. Gastroenterology. 1993 Nov;105(5):1464-70. [Content Brief]

[4]. Molnár M, Hertelendy F. N omega-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am J Obstet Gynecol. 1992 May;166(5):1560-7. [Content Brief]

NG-nitro-L-arginine 相关分类

Cardiovascular Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5620 mL	22.8102 mL	45.6204 mL	114.0511 mL
	5 mM	0.9124 mL	4.5620 mL	9.1241 mL	22.8102 mL
	10 mM	0.4562 mL	2.2810 mL	4.5620 mL	11.4051 mL
	15 mM	0.3041 mL	1.5207 mL	3.0414 mL	7.6034 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NG-nitro-L-arginine2149-70-4Nω-nitro-L-arginine L-NOARG L-NG-NitroarginineNO SynthaseNitric oxide synthasesNOShypertensiveInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NG-nitro-L-arginine (Synonyms: Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine)