1. Stem Cell/Wnt
  2. Wnt β-catenin
  3. NLS-StAx-h TFA

NLS-StAx-h TFA 是选择性的、细胞可渗透的 Wnt 信号传导的固定肽抑制剂,IC50 为 1.4 μM。NLS-StAx-h TFA 可有效抑制 β-catenin-转录因子的相互作用,具有对癌细胞的抗增殖活性。

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Custom Peptide Synthesis

NLS-StAx-h TFA Chemical Structure

NLS-StAx-h TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
100 μg ¥4000
In-stock
500 μg ¥8000
In-stock

* Please select Quantity before adding items.

Customer Review

Other Forms of NLS-StAx-h TFA:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells[1][2].

IC50 & Target

IC50: 1.4 μM (Wnt)[1]

体外研究
(In Vitro)

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW-480 and DLD-1 cells
Concentration: 10 μM
Incubation Time: 72 hr
Result: Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay [1]

Cell Line: DLD-1 cells
Concentration: 5 and 10 μM
Incubation Time: 24 hr
Result: Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).
分子量

3559.28

Formula

C162H276F3N55O31

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (28.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2810 mL 1.4048 mL 2.8096 mL
5 mM 0.0562 mL 0.2810 mL 0.5619 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NLS-StAx-h TFA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2810 mL 1.4048 mL 2.8096 mL 7.0239 mL
5 mM 0.0562 mL 0.2810 mL 0.5619 mL 1.4048 mL
10 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7024 mL
15 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
20 mM 0.0140 mL 0.0702 mL 0.1405 mL 0.3512 mL
25 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2810 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NLS-StAx-h TFA
目录号:
HY-P2272A
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