2. Immunology/Inflammation
  3. NO Synthase
  4. NOS-IN-3

NOS-IN-3 (Compound 9a) 是一个强效的、选择性的由 imidamide 衍生的 NOS 抑制剂，对 iNOS 的 IC50 值为20 μM。NOS-IN-3 不抑制 eNOS，几乎没有毒性，可用于研究可诱导亚型涉及的疾病，如感染性休克。

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NOS-IN-3 Chemical Structure

NOS-IN-3 Chemical Structure

CAS No. : 2761725-68-0

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NOS-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 μM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the research of inducible isoform involved diseases, such as septic shock[1].

IC50 & Target

iNOS

 

nNOS

 

体外研究
(In Vitro)

NOS-IN-3 (Compound 9a) shows high iNOS selectivity without eNOS inhibition activity [1].
NOS-IN-3 (0-100 µM, 30 min) has little toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NOS-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 10, 20, 50, 100, 500 µM
Incubation Time: 30 min
Result: Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
分子量

193.25

Formula

C10H15N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NOS-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOS-IN-32761725-68-0NO SynthaseNitric oxide synthasesNOSImidamideLow toxicityHUVECsInhibitorinhibitorinhibit

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目录号：
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