2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. NUDT5/14 antagonist 1

NUDT5/14 antagonist 1 (Compound 9) 是核苷酸二磷酸激酶 NUDT5 和 NUDT14 的双重选择性拮抗剂，IC50 为 0.27 和 0.16 μM。NUDT5/14 antagonist 1 与 Bruton’s tyrosine kinase (BTK) 结合，IC50 为 0.377 μM。

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NUDT5/14 antagonist 1 Chemical Structure

NUDT5/14 antagonist 1 Chemical Structure

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NUDT5/14 antagonist 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

NUDT5/14 antagonist 1 (Compound 9) is a selective, dual antagonist for nucleotide diphosphate kinase NUDT5 and NUDT14, with IC50 of 0.27 and 0.16 μM, respectively. NUDT5/14 antagonist 1 binds to Bruton’s tyrosine kinase (BTK) with an IC50 of 0.377 μM[1].

IC50 & Target

IC50: 0.27 μM (NUDT5), 0.16 μM (NUDT14)
体外研究
(In Vitro)

NUDT5/14 antagonist 1 (>10 μM，72 h) 在癌细胞 BT-474 中不具备细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NUDT5/14 antagonist 1 相关抗体:

Cell Viability Assay[1]

Cell Line: BT-474
Concentration: >10 μM
Incubation Time: 72 h
Result: Maintained cell viability with concentration of 10 μM.
分子量

400.48

Formula

C23H24N6O
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NUDT5/14 antagonist 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NUDT5/14 antagonist 1DNA/RNA SynthesisHEK293U2OSosteosarcomaBT-474Inhibitorinhibitorinhibit

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