2. 寡核苷酸
  3. 反义寡核苷酸
  4. Olezarsen

Olezarsen  (Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx)

目录号: HY-153491
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Olezarsen 是一种靶向肝脏 APOC3 mRNA 的反义寡核苷酸，抑制载脂蛋白 C-III (apoC-III) 的产生，用于降低高危或已确定心血管疾病患者的甘油三酯水平。

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DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]

Olezarsen Chemical Structure

CAS No. : 2097587-83-0

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Olezarsen 相关抗体

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生物活性

Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

Clinical Trial
CAS 号
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Keywords:

Olezarsen2097587-83-0ISIS 678354 IONIS-APOCIII-LRx AKCEA-APOCIII-LRxISIS678354ISIS-678354OthersAPOC3ApolipoproteinTriglycerideInhibitorinhibitorinhibit

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