2. Anti-infection
  3. Fungal
  4. P163-0892

P163-0892 是一种对 Cryptococcus 种具有强选择性的抗真菌剂（antifungal）。P163-0892 被预测具有中等程度的血脑屏障透过性。

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P163-0892 Chemical Structure

P163-0892 Chemical Structure

CAS No. : 1574576-45-6

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P163-0892 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration[1].

体外研究
(In Vitro)

P163-0892 (0-32 μg/mL; 48 h) shows antifungal activity with a MIC of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively[1].
P163-0892 has good aqueous solubility[1].
P163-0892 has no cytotoxicity and no obvious cardiotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P163-0892 相关抗体:
体内研究
(In Vivo)

P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wax moth larva infected with C. neoformans H99 or C. gattii WM178[1]
Dosage: 10 mg/kg
Administration: 5 days
Result: Increased the survival rate of larvae.
Animal Model: Male Sprague–Dawley rats weighing 200–250 g[1]
Dosage: 2 mg/kg or 5 mg/kg
Administration: Intravenous or oral administration (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of P163-0892a[1]
route dose (mg/kg) T1/2 (h) Tmax (h) AUC0-inf (h•ng/mL) Cl (mL/h/kg) MRT0-t (h) Vdss (L/kg) BA (%)
iv 2 mg/kg 7.61 749 172 2.63 7.12
po 5 mg/kg 15.3 3.17 NR 3.83 NR 0.8

aAbbreviations: iv, intravenous; po, per os; T1/2, half-life elimination in hours; Tmax, time of maximal concentration in hours; AUC, area under the curve; Cl, clearance; MRT, mean residence time; Vdss, volume of distribution at the steady state; BA, bioavailability; NR, not reportable; n = 3.
分子量

356.44

Formula

C19H20N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P163-0892 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P163-08921574576-45-6FungalCryptococcus neoformansCryptococcus gattiihepatotoxicitywax moth larvaInhibitorinhibitorinhibit

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产品名称：
P163-0892
目录号：
HY-150972
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