2. Apoptosis
  3. MDM-2/p53
  4. p53 Activator 8

p53 Activator 8 是一种 p53 激活剂。p53 Activator 8 对 MCF7 乳腺癌细胞系具有有效的抗增殖活性，IC50 值为 0.5 μM。

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p53 Activator 8

p53 Activator 8 Chemical Structure

CAS No. : 1426937-93-0

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p53 Activator 8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC50 value of 0.5 μM[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
13.2 μM
Compound: 1; MANIO
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 38784460]
HCC1806 IC50
28.7 μM
Compound: 6
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay
[PMID: 24747064]
HCC1806 IC50
63.1 μM
Compound: 6
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay
[PMID: 24747064]
HCC1806 IC50
78.5 μM
Compound: 6
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay
[PMID: 24747064]
HCC1806 IC50
> 100 μM
Compound: 6
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay
Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay
[PMID: 24747064]
HCC1954 IC50
11.8 μM
Compound: 6
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay
[PMID: 24747064]
HCC1954 IC50
14.8 μM
Compound: 6
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 24747064]
HCC1954 IC50
56.8 μM
Compound: 6
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 24747064]
HCC1954 IC50
> 100 μM
Compound: 6
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 24747064]
HCT-116 IC50
0.97 μM
Compound: 1; MANIO
Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 38784460]
HCT-116 IC50
0.97 μM
Compound: 21; MANIO
Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay
[PMID: 38142509]
HCT-116 IC50
48.25 μM
Compound: 1; MANIO
Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 38784460]
MCF7 IC50
0.3 μM
Compound: 36
Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
[PMID: 23313634]
MCF7 IC50
0.54 μM
Compound: 36
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 23313634]
MCF7 IC50
0.54 μM
Compound: 36
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 23313634]
MCF7 IC50
1.75 μM
Compound: 36
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 23313634]
MDA-MB-231 IC50
> 50 μM
Compound: 1; MANIO
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 38784460]
PANC-1 IC50
42.15 μM
Compound: 1; MANIO
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 38784460]
分子量

275.37

Formula

C15H17NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p53 Activator 8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Activator 81426937-93-0MDM-2/p53p53 ActivatorAntitumorInhibitorinhibitorinhibit

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