2. Anti-infection Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Antibiotic Bacterial Fungal Apoptosis Reactive Oxygen Species (ROS) TNF Receptor NO Synthase Interleukin Related NF-κB Toll-like Receptor (TLR)
  4. Papiliocin

Papiliocin 是一种兼具抗炎和抗菌活性的强效肽类抗生素。Papiliocin 主要对革兰氏阴性菌有活性。Papiliocin 对细胞具有较高的抗炎活性，通过抑制 NO 的产生以及 TNF-α 和 MIP-2 的分泌来发挥其抗炎活性。Papiliocin 通过抑制 Toll 样受体 (Toll-like Receptor) 通路和 NF-κB 参与先天防御反应机制。Papiliocin 诱导真菌 (fungal) 细胞凋亡 (apoptosis), 诱导细胞内 ROS 总水平升高。Papiliocin 在脓毒症模型中充当有效的防腐肽。Papiliocin 可用于抗炎和抗菌研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Papiliocin

Papiliocin Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Papiliocin 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Papiliocin is a potent peptide antibiotic with both anti-inflammatory and antibacterial activities. Papiliocin is primarily active against Gram-negative bacteria. Papiliocin exhibits strong anti-inflammatory activity against cell, exerting its anti-inflammatory activity by inhibiting the production of NO and the secretion of TNF-α and MIP-2. Papiliocin participates in the innate defense response mechanism by inhibiting the Toll-like receptor pathway and NF-κB. Papiliocin induces apoptosis in fungal cells and increases the total level of intracellular ROS. Papiliocin acts as an effective antiseptic peptide in sepsis models. Papiliocin is useful in anti-inflammatory and antibacterial research[1][3].

IC50 & Target[1]

IL-1β

 

IL-6

 

TLR4

 

iNOS

 

体外研究
(In Vitro)

Papiliocin (37 °C 下 16 小时) 对革兰氏阴性菌 (大肠杆菌、鼠伤寒沙门氏菌和铜绿假单胞菌) 和革兰氏阳性菌 (枯草芽孢杆菌、表皮葡萄球菌和金黄色葡萄球菌) 具有抗菌活性，MIC 分别为 0.25、0.5、1、16、2、32 μM[1]。
Papiliocin 对革兰氏阴性菌具有钙和镁耐受性[1]。
Papiliocin (0-100 μM，37 °C 下 1 小时) 缺乏溶血活性，对 RAW264.7 细胞无细胞毒性，IC50 为 58 μm[1]。
Papiliocin (0-25 μM，3-24 小时) 可抑制 LPS (HY-D1056) 刺激的 RAW264.7 细胞中 NO、TNF-α、MIP-2、iNOS、TLR4、NF-κB 以及所有炎症细胞因子 IL-1β、IL-6、MIP-1、MIP-2 和 TNF-α 基因的表达[1]。
Papiliocin (0-10 μM) 可诱导脂质囊泡通透性，在胶束或 SUV 中表现出较低的 Stern-Volmer 猝灭常数 (KSV)，并通过与 LPS 聚集体的相互作用导致 LPS 聚集体的解离[1]。
Papiliocin (30 μM，28 °C，2 小时) 可诱导白色念珠菌细胞中 ROS 的产生，并增加细胞内羟基自由基水平[2]。
Papiliocin (30 μM，28 °C，2 小时) 可诱导白色念珠菌细胞中细胞凋亡、膜去极化和间质胱天蛋白酶活化，以及 DNA 损伤[2]。
Papiliocin (0-50 μM) 可取代 LPS 上 74.6% 的 BC 探针，并中和 LPS，结合亲和力为 0.063 μM[3]。
Papiliocin (40 μM，30 分钟) 可抑制 52% 的 FITC-LPS 与 RAW 264.7 细胞表面的结合，同时竞争性地取代 RAW 264.7 细胞上 LPS-受体复合物上 25% 的预结合 LPS[3]。
Papiliocin (0-100 μM) 可降低 TLR4 介导的 SEAP 活性，IC50 为 1.1 μM[3]。
Papiliocin (0.1-10 μM，1 小时) 可阻断 LPS 诱导的炎症通过靶向 TLR4 和 MAPK 通路以及阻断 RAW 264.7 细胞中的 p-NF-κB 核易位来产生级联[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Papiliocin 相关抗体:

ELISA Assay[1]

Cell Line: LPS (20 ng/mL)-stimulated RAW264.7 cells
Concentration: 1, 10 μM
Incubation Time: 18  h
Result: Inhibited the production of TNF-α and MIP-2.

RT-PCR[1]

Cell Line: LPS (20 ng/mL)-stimulated RAW264.7 cells
Concentration: 20 μM
Incubation Time: 3  h
Result: Inhibited the expression of iNOS and all inflammatory cytokines, including IL-1β, IL-6, MIP-1, MIP-2, and TNF-α.

Western Blot Analysis[1]

Cell Line: LPS (20 ng/mL)-stimulated RAW264.7 cells
Concentration: 25 μM
Incubation Time: 24  h
Result: Inhibited TLR4 and NF-κB expression and prevented the translocation of NF-κB from the cytoplasm to the nucleus.

Apoptosis Analysis[2]

Cell Line: Candida albicans cells
Concentration: 30 μM
Incubation Time: 28 °C for 2 h
Result: Induced apoptosis cell death, with the early apoptotic cells of 61.14%, the late apoptotic of 0.52%.
Induced the breakdown of ΔΨm and the loss of mitochondrial permeability.
Induced the generation of strong oxidant hydroxyl radicals.
Increased the proportion of TUNEL-positive cell nuclei.

Western Blot Analysis[3]

Cell Line: LPS (50 ng/mL)-stimulated RAW264.7 cells
Concentration: 0.1, 0.5, 1 μM
Incubation Time: 1  h
Result: Reduced MyD88 overexpression and phosphorylation levels of TAK1, p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK).

Immunofluorescence[3]

Cell Line: LPS (50 ng/mL)-stimulated RAW264.7 cells
Concentration: 10 μM
Incubation Time: 1  h
Result: Reduced expression of Alexa 546 inhibited Lp-NF-κB p65 translocation.
分子量

4002.80

Formula

C183H314N56O44
Sequence

Arg-Trp-Lys-Ile-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Arg-Asn-Val-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Ala-Thr-Val-Val-Lys-NH2
Sequence Shortening

RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Papiliocin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PapiliocinAntibioticBacterialFungalApoptosisReactive Oxygen Species (ROS)TNF ReceptorNO SynthaseInterleukin RelatedNF-κBToll-like Receptor (TLR)Tumor Necrosis Factor ReceptorTNFRNitric oxide synthasesNOSILNuclear factor-κBNuclear factor-kappaBanti-inflammatoryantibacterialRAW264.7 cellsapoptosispeptide antibioticInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Papiliocin
目录号：
HY-P11093
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z