2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Parsatuzumab

Parsatuzumab  (Synonyms: Anti-EGFL7; RG 7414)

目录号: HY-P99215 纯度: 96.52%
COA

摩尔计算器

Parsatuzumab (Anti-EGFL7; RG 7414) 是一种人源化单克隆抗体，作为免疫调节剂与 EGFL7 结合。Parsatuzumab 选择性阻断 EGFL7 与内皮细胞之间的相互作用，可能抑制血管再生，降低血管内皮生长因子 (VEGF) 抑制。

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Parsatuzumab Chemical Structure

Parsatuzumab Chemical Structure

CAS No. : 1312797-14-0

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规格 价格 是否有货 数量
1 mg ￥1500
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5 mg ￥3900
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10 mg ￥6250
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Parsatuzumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition[1].

IC50 & Target

VEGF; EGFL7[1]
体外研究
(In Vitro)

EGFL7 is a vascular-restricted extracellular matrix protein that promotes endothelial cell adhesion and survival[1].
Parsatuzumab (48 h) inhibits cell proliferation and increases apoptosis against patient-derived xenograft (PDX) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Parsatuzumab 相关抗体:

Cell Viability Assay[2]

Cell Line: Patient-derived xenograft (PDX) cells
Concentration: /
Incubation Time: 48 hours
Result: Inhibited cell proliferation by 70% from 20%, and resulted in apoptosis increases by 67-87% from 8-17%.
体内研究
(In Vivo)

Parsatuzumab (anti-EGFL7) enhances the antiangiogenesis, tumor growth control, and survival associated with antiVEGF monotherapy in several xenograft and genetically engineered murine tumor models[1].
Parsatuzumab (50 mg/kg; i.v.; 3 times per week) targets EGFL7 and inhibits mantle cell lymphoma (MCL) cell growth and prolongs survival in mouse models of MCL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice injected with Rec1 cells (s.c.)[2]
Dosage: 50 mg/kg
Administration: Intravenous injection; 3 times per week; sacrificed mice when tumor reached end point criteria
Result: Significantly decreased tumor volume than IgG and increased survival of mice.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Parsatuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Parsatuzumab1312797-14-0Anti-EGFL7 RG 7414RG7414RG 7414RG-7414VEGFRVascular endothelial growth factor receptormetastatic colorectal cancernonsquamous non-small cell lung cancermantle cell lymphomapatient-derived xenograft cellsPDXvascular endothelial growth factorVEGFInhibitorinhibitorinhibit

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