2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Pentixather

Pentixather 是一种可靶向 CXCR4 的放射性标记肽。Pentixather 通过靶向 CXCR4/CXCL12 信号轴，破坏白血病细胞与骨髓微环境的相互作用，减少白血病细胞在保护性骨髓龛中的滞留，从而增强白血病细胞对治疗的敏感性。Pentixather 可用于急性淋巴细胞白血病 (ALL) 和急性髓系白血病 (AML) 研究。

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Custom Peptide Synthesis

Pentixather

Pentixather Chemical Structure

CAS No. : 1339959-27-1

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Pentixather 相关抗体

Top Publications Citing Use of Products

查看 CXCR 亚型特异性产品:

查看所有亚型
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pentixather is a radiolabeled peptide that can target CXCR4. Pentixather can disrupt the interaction between leukemic cells and the bone marrow microenvironment by targeting the CXCR4/CXCL12 signaling axis, reduce the retention of leukemic cells in the protective bone marrow niche, and thereby enhance the sensitivity of leukemic cells to treatment. Pentixather can be used for the study of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

IC50 & Target[1]

CXCR4

 

分子量

701.82

Formula

C36H47N9O6
CAS 号
Sequence

Cyclo(dTyr-dOrn(NMe)-Arg-Nal-Gly)
Sequence Shortening

Cyclo(dTyr-dOrn(NMe)-R-Nal-G)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pentixather 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentixather1339959-27-1CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsradiolabeled peptideCXCR4acute lymphoblastic leukemiaacute myeloid leukemiaInhibitorinhibitorinhibit

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目录号：
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