2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. PF-05186462

PF-05186462 是一种有效和选择性的人 Nav1.7 电压依赖性钠通道抑制剂，IC50 值为 21 nM。PF-05186462 对 Nav1.7 与其他钠通道 (Nav 1.1、1.2、1.3、1.4、1.5、1.6 和 1.8) 相比显示出显着的选择性。PF-05186462 可用于急性或慢性疼痛的研究。

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PF-05186462 Chemical Structure

PF-05186462 Chemical Structure

CAS No. : 1235406-03-7

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规格 价格 是否有货 数量
1 mg ￥2210
1 周
5 mg   询价  
10 mg   询价  

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PF-05186462 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1].

IC50 & Target

IC50: 21 nM (human Nav1.7)[1]
体外研究
(In Vitro)

PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells[1].
PF-05186462 exhibits a high plasma protein binding rate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-05186462 相关抗体:
Clinical Trial
分子量

531.89

Formula

C19H10ClF4N5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-05186462 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-051864621235406-03-7PF05186462PF 05186462Sodium ChannelNa channelsNa+ channelsNav1.7voltagesodiumchannelacutechronicpainInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-122001
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