1. NF-κB Stem Cell/Wnt MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  2. NF-κB ERK JNK Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related MMP
  3. Phloroglucinol

Phloroglucinol 是一种有效的 NIK 抑制剂,具有抗氧化和抗炎活性。Phloroglucinol 抑制核因子-κB (NF-κB)、细胞外信号调节激酶 (ERK) 和 c-Jun N-末端激酶 (JNK) 等信号通路,清除活性氧 (ROS) ,降低炎症介质 (如 TNF-α、IL-1β、IL-6、PGE2) 和基质金属蛋白酶 (MMPs) 的表达。Phloroglucinol 有望用于关节炎、动脉粥样硬化等慢性炎症相关疾病的研究。

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Phloroglucinol Chemical Structure

Phloroglucinol Chemical Structure

CAS No. : 108-73-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phloroglucinol is a potent NIK inhibitor with antioxidant and anti-inflammatory activities. Phloroglucinol inhibits signaling pathways such as nuclear factor-κB (NF-κB), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK), scavenges reactive oxygen species (ROS), and decreases the expression of inflammatory mediators (such as TNF-α, IL-1β, IL-6, PGE2) and matrix metalloproteinases (MMPs). Phloroglucinol is promising for research of chronic inflammation-related diseases like arthritis and atherosclerosis[1][2].

分子量

126.11

Formula

C6H6O3

CAS 号
性状

固体

颜色

White to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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