2. NF-κB Stem Cell/Wnt MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. NF-κB ERK JNK Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related MMP
  4. Phloroglucinol

Phloroglucinol 是一种有效的 NIK 抑制剂，具有抗氧化和抗炎活性。Phloroglucinol 抑制核因子-κB (NF-κB)、细胞外信号调节激酶 (ERK) 和 c-Jun N-末端激酶 (JNK) 等信号通路，清除活性氧 (ROS) ，降低炎症介质 (如 TNF-α、IL-1β、IL-6、PGE2) 和基质金属蛋白酶 (MMPs) 的表达。Phloroglucinol 有望用于关节炎、动脉粥样硬化等慢性炎症相关疾病的研究。

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Phloroglucinol Chemical Structure

Phloroglucinol Chemical Structure

CAS No. : 108-73-6

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Phloroglucinol 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phloroglucinol is a potent NIK inhibitor with antioxidant and anti-inflammatory activities. Phloroglucinol inhibits signaling pathways such as nuclear factor-κB (NF-κB), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK), scavenges reactive oxygen species (ROS), and decreases the expression of inflammatory mediators (such as TNF-α, IL-1β, IL-6, PGE2) and matrix metalloproteinases (MMPs). Phloroglucinol is promising for research of chronic inflammation-related diseases like arthritis and atherosclerosis[1][2].

分子量

126.11

Formula

C6H6O3
CAS 号
性状

固体

颜色

White to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

Phloroglucinol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phloroglucinol108-73-6NF-κBERKJNKReactive Oxygen Species (ROS)TNF ReceptorInterleukin RelatedMMPNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesc-Jun N-terminal kinaseTumor Necrosis Factor ReceptorTNFRILMatrix metalloproteinasesNIKROSchronic inflammation-related diseasesInhibitorinhibitorinhibit

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