1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. mAChR iGluR
  3. Procyclidine

Procyclidine  (Synonyms: Tricyclamol; (±)-Procyclidine)

目录号: HY-B1487A
产品使用指南

Procyclidine (Tricyclamol; (±)-Procyclidine) 是一种有效的抗胆碱能试剂,毒蕈碱受体 (muscarinic receptor) 拮抗剂,也具有 N-甲基-D-天冬氨酸 (NMDA) 拮抗剂的特性。可用作帕金森症以及 Soman 诱发的癫痫等相关精神疾病研究。

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Procyclidine Chemical Structure

Procyclidine Chemical Structure

CAS No. : 77-37-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

体内研究
(In Vivo)

Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1]
Dosage: 0.3-6.0 mg/kg
Administration: Subcutaneous injection; once
Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.
Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
分子量

287.44

Formula

C19H29NO

CAS 号
中文名称

丙环利定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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