1. PROTAC
    Epigenetics
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    Epigenetic Reader Domain
  3. PROTAC BRD4 Degrader-5

PROTAC BRD4 Degrader-5 

目录号: HY-133737
产品使用指南

PROTAC BRD4 Degrader-5 是一种基于 PROTAC 的 BRD4 降解剂,可有效降解 HER2 阳性和阴性乳腺癌细胞系中的 BRD4

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PROTAC BRD4 Degrader-5 Chemical Structure

PROTAC BRD4 Degrader-5 Chemical Structure

CAS No. : 2409538-70-9

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Description

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

IC50 & Target[1]

BRD4

 

In Vitro

PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1].

Western Blot Analysis[1]

Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells
Concentration: 5 nM, 10 nM, 50 nM, 100 nM
Incubation Time: 4 hours
Result: Degradation of BRD4 in MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cell.
Molecular Weight

1016.67

Formula

C₅₀H₆₂ClN₉O₈S₂

CAS No.

2409538-70-9

SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC BRD4 Degrader-5PROTACEpigenetic Reader DomainProteolysis-targeting chimeraVHLBRD4degraderPEGInhibitorinhibitorinhibit

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产品名称:
PROTAC BRD4 Degrader-5
目录号:
HY-133737
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