2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Immunology/Inflammation NF-κB Apoptosis Epigenetics
  3. Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA
  4. Protectin D1

Protectin D1  (Synonyms: Neuroprotectin D1; NPD1)

目录号: HY-130413 纯度: 99.10%
COA 产品使用指南 技术支持

Protectin D1，神经细胞产生的神经保护素 D1，是由二十二碳六烯酸产生的一个新的生物活性产品家族的成员。Protectin D1 还是一种专门的促分解介质，在多种人类疾病模型中具有有效的体内促分解作用。同时，Protectin D1 是一种 NALP3 炎性小体的抑制剂，能够调节 PI3K/AKT 和 HIF-1α 信号通路。Protectin D1 通过降低 ROS 水平，抑制 NALP3、ASC 和 Caspase-1 的表达，从而减少 IL-1β 和 IL-18 等促炎因子的释放，发挥抗炎作用。此外，Protectin D1 通过上调 miRNA-210，促进 PI3K/AKT 信号通路激活，发挥心脏保护作用。Protectin D1 有望用于心血管疾病和炎症疾病的研究。

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Protectin D1 Chemical Structure

Protectin D1 Chemical Structure

CAS No. : 660430-03-5

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规格 价格 是否有货 数量
10 μg (138.7 µM * 200 μL in ethanol) ￥2950
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Protectin D1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

IL-1β

 

体外研究
(In Vitro)

Protectin D1 (1 μM, 24h) 通过上调 miRNA-210 表达和激活 PI3K/AKT 信号通路，在新生大鼠心肌细胞中发挥保护作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Protectin D1 相关抗体:

Real Time qPCR[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Upregulated miRNA-210 expression.

Western Blot Analysis[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Increased p-AKT and HIF-1α protein levels.
体内研究
(In Vivo)

Protectin D1 (0.5 和 1 μM/kg，腹腔注射，一天一次共 3 天) 通过抑制氧化应激和炎症，改善 I/R 诱导的急性心肌梗死大鼠模型中的心脏功能，并减少梗死面积[3]。
Protectin D1 (0.08 mg/kg，腹腔注射，单次给药) 通过降低 ROS 浓度来抑制 NALP3 炎性小体的激活，并减少促炎细胞因子水平，在 CLP 诱导的脓毒症大鼠模型中发挥抗炎作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: I/R-induced acute myocardial infarction (AMI) rat model, male Sprague Dawley rats (8 weeks old)[3]
Dosage: 0.5 μM/kg, 1 μM/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 days before surgery
Result: Significantly reduced I/R-induced heart rate (HR), improved left ventricular ejection fraction (EF%) and fractional shortening (FS%), and reduced myocardial infarction area.
Animal Model: Cecal ligation and puncture (CLP)-induced sepsis Wistar rat model (8 weeks old, 200 g)[4]
Dosage: 0.08 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose (12 hours before surgery)
Result: Significantly reduced ROS concentration in hepatocytes of CLP-induced rats, decreased NALP3, ASC, and Caspase-1 expression levels, and lowered serum IL-18 and IL-1β concentrations.
分子量

360.49

同用名

Neuroprotectin D1; NPD1

Formula

C22H32O4
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: 99.10%

COA (277 KB)

产品使用指南 (1538 KB)
参考文献

Protectin D1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protectin D1660430-03-5Neuroprotectin D1 NPD1Protectin D 1Protectin D-1Neuroprotectin D 1Neuroprotectin D-1NPD1NPD 1NPD-1Endogenous MetabolitePI3KAktHIF/HIF Prolyl-HydroxylaseReactive Oxygen Species (ROS)CaspaseInterleukin RelatedMicroRNAPhosphoinositide 3-kinasePKBProtein kinase BHypoxia-inducible factorsHIFsHIF-PHILmiRNAneuroprotectin D1neural celldocosahexaenoic acidpro-resolvinganti-inflammatoryInhibitorinhibitorinhibit

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