1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins
  4. Integrin Associated Protein/CD47
  5. CD47 蛋白, Rat (HEK293, Fc)

CD47 蛋白, Rat (HEK293, Fc)

目录号: HY-P75402
COA 产品使用指南

CD47 蛋白作为 THBS1 受体并调节整合素信号传导,促进细胞间相互作用。它在信号转导、心血管稳态、炎症、细胞凋亡、血管生成、免疫调节和记忆形成中发挥作用。CD47 与 SIRPA、SIRPG、FAS/CD95、UBQLN1、UBQLN2 和纤维蛋白原相互作用,增强粘附、T 细胞增殖和激活。它抑制血管生成,调节伤口愈合和干细胞自我更新,并防止红细胞过早消除。CD47 影响肺内皮素信号传导、NO 信号传导和血压调节。它还可能导致衰老过程中的代谢失调。CD47 蛋白, Rat (HEK293, Fc) 是重组的 CD47 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD47 蛋白, Rat (HEK293, Fc) 全长 122 个氨基酸,分子量为 50-70 kDa。

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规格 价格 是否有货 数量
Free Sample   Apply now  
5 μg ¥450 In-stock
10 μg ¥760 In-stock
50 μg ¥2120 In-stock
100 μg ¥3600 In-stock
500 μg ¥10080 询价
1 mg ¥17000 询价
> 100 μg   询价  

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描述

CD47 protein, acting as a receptor for THBS1 and modulating integrin signaling, facilitates cell-to-cell interactions. It plays roles in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, immunoregulation, and memory formation. CD47 interacts with SIRPA, SIRPG, FAS/CD95, UBQLN1, UBQLN2, and fibrinogen, enhancing adhesion, T-cell proliferation, and activation. It suppresses angiogenesis, regulates wound healing and stem cell self-renewal, and prevents premature elimination of red blood cells. CD47 influences pulmonary endothelin signaling, NO signaling, and blood pressure regulation. It may also contribute to metabolic dysregulation during aging. CD47 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD47 protein, expressed by HEK293, with C-hFc labeled tag. The total length of CD47 Protein, Rat (HEK293, Fc) is 122 a.a., with molecular weight of 50-70 kDa.

研究背景

CD47 蛋白是一种促进细胞间相互作用的粘附蛋白。它作为血小板反应蛋白 THBS1 的受体,并通过激活异三聚体 G 蛋白来调节整合素信号传导。CD47参与多种生物过程,包括信号转导、心血管稳态、炎症、细胞凋亡、血管生成、细胞自我更新和免疫调节。它还在调节肺内皮素 EDN1 信号和一氧化二氮 (NO) 信号中发挥作用,有助于血压调节。此外,CD47 对于海马体的记忆形成和突触可塑性也很重要。它作为 SIRPA 的受体,防止未成熟树突状细胞的成熟并抑制成熟树突状细胞产生细胞因子。与 SIRPG 的相互作用可增强细胞间粘附、T 细胞增殖和 T 细胞活化。CD47 正向调节 T 细胞中 FAS 依赖性细胞凋亡并抑制血管生成。它还可能参与正常衰老过程中的代谢失调,并调节伤口愈合和干细胞自我更新。CD47 可能在膜运输、整合素依赖性信号转导和防止红细胞过早消除中发挥作用。它与 THBS1、SIRPA、FAS/CD95、SIRPG、UBQLN1、UBQLN2 和纤维蛋白原相互作用。

生物活性

1.Immobilized Mouse SIRP alpha, His Tag at 2 μg/mL (100μl/well) on the plate. Dose response curve for Rat CD47, hFc Tag with the EC50 of 88.7 ng/mL determined by ELISA.
2.Measured by its binding ability in a functional ELISA. Immobilized Rat CD47 at 10 μg/mL (100 μL/well) can bind Biotinylated Mouse SIRP alpha. The ED50 for this effect is 0.387 μg/mL.

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

P97829 (Q19-K140)

基因 ID

29364  [NCBI]

蛋白结构
N-term
CD47 (Q19-K140)
Accession # P97829
hFc
C-term
同用名
Leukocyte Surface Antigen CD47; IAP; CD47; MER6
氨基酸序列

QLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEK

分子量

50-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD47 Protein, Rat (HEK293, Fc)
目录号:
HY-P75402
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