1. 重组蛋白
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Coxsackievirus and Adenovirus Receptor (CXADR)
  6. CXADR 蛋白, Mouse (HEK293, Fc)

CXADR 蛋白, Mouse (HEK293, Fc)

目录号: HY-P70052
COA 产品使用指南

CXADR 蛋白是上皮顶端连接复合物的关键成分,它维持紧密连接的完整性,并通过与 JAML 的粘附相互作用使白细胞迁移。这种相互作用激活 γ-δ T 细胞,并通过涉及 PI3 激酶和 MAP 激酶的细胞信号传导促进组织修复。CXADR 蛋白, Mouse (HEK293, Fc) 是重组的 CXADR 蛋白,由 HEK293 表达,带有 C-hFc 标签。CXADR 蛋白, Mouse (HEK293, Fc) 全长 218 个氨基酸,分子量为 50-70 kDa。

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规格 价格 是否有货 数量
10 μg ¥850 In-stock
50 μg ¥2400 In-stock
100 μg ¥4000 In-stock
500 μg ¥11400 In-stock
1 mg ¥17000 In-stock
> 100 μg   询价  

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描述

CXADR protein is a key component of the epithelial apical junction complex, which maintains the integrity of tight junctions and enables leukocyte migration through adhesive interactions with JAML. This interaction activates γ-δ T cells and promotes tissue repair through cell signaling involving PI3 kinase and MAP kinase. CXADR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CXADR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CXADR Protein, Mouse (HEK293, Fc) is 218 a.a., with molecular weight of 50-70 kDa.

研究背景

作为上皮顶端连接复合物的重要组成部分,CXADR 具有双重作用:作为同种细胞粘附分子维持紧密连接完整性,并通过与跨膜蛋白类连接粘附分子 (JAML) 的粘附相互作用促进白细胞的跨上皮迁移白细胞质膜上。CXADR 和 JAML 之间的这种相互作用对于激活 γ-δ T 细胞至关重要,γ-δ T 细胞是一种存在于上皮组织中的特殊 T 细胞亚群,有助于组织稳态和修复。与 CXADR 结合后,JAML 通过涉及 PI3 激酶和 MAP 激酶的途径启动 γ-δ T 细胞中的下游细胞信号传导,导致 T 细胞增殖以及细胞因子和生长因子的产生。这反过来又刺激上皮组织的修复。CXADR 可能以单体形式存在或形成同型二聚体,它与多种蛋白质相互作用,包括 LNX、MAGI1、DLG4、PRKCABP、TJP1、CTNNB1 和 MPDZ,后者将 MPDZ 招募到细胞间接触位点。此外,CXADR 与 JAML 发生同二聚体相互作用,有助于其多方面的细胞功能。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

P97792 (L20-G237)

基因 ID

13052  [NCBI]

蛋白结构
N-term
CXADR (L20-G237)
Accession # P97792
hFc
C-term
同用名
rMuCoxsackievirus and adenovirus receptor homolog/CXADR, Fc; Coxsackievirus and adenovirus receptor homolog; CAR; Cxadr; CVB3 BP
氨基酸序列

LSITTPEQRIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPSDNQIVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKFLLTVLVKPSGTRCFVDGSEEIGNDFKLKCEPKEGSLPLQFEWQKLSDSQTMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRVGSDQCMLRLDVVPPSNRAG

分子量

50-70 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Or lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CXADR Protein, Mouse (HEK293, Fc)
目录号:
HY-P70052
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