1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  3. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. FGFR-2/CD332 FGFR
  5. FGFR-2
  6. FGFR-2 beta IIIc 蛋白, Human (267a.a, HEK293, His)

FGFR-2 beta IIIc 蛋白, Human (267a.a, HEK293, His)

目录号: HY-P76335
产品使用指南

FGFR-2 beta IIIc 蛋白是成纤维细胞生长因子受体家族的一部分,具有保守序列。其全长结构包括细胞外免疫球蛋白样结构域、跨膜片段和酪氨酸激酶结构域。FGFR-2 beta IIIc 蛋白, Human (267a.a, HEK293, His) 是重组的 FGFR-2 β IIIc 蛋白,由 HEK293 表达,带有 C-His 标签。FGFR-2 beta IIIc 蛋白, Human (267a.a, HEK293, His) 全长 267 个氨基酸,分子量约为 ~31.2 KDa。

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描述

The FGFR-2 beta IIIc protein is part of the fibroblast growth factor receptor family and has a conserved sequence. Its full-length structure includes an extracellular immunoglobulin-like domain, a transmembrane segment, and a tyrosine kinase domain. FGFR-2 beta IIIc Protein, Human (267a.a, HEK293, His) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 beta IIIc Protein, Human (267a.a, HEK293, His) is 267 a.a., with molecular weight of ~31.2 KDa.

研究背景

FGFR-2 beta IIIc 蛋白是成纤维细胞生长因子受体家族的成员,在家族成员之间和整个进化过程中表现出高度保守的氨基酸序列。该全长蛋白的特点是配体亲和力和组织分布的变化,包含一个具有三个免疫球蛋白样结构域的胞外区域、一个疏水性跨膜片段和一个细胞质酪氨酸激酶结构域。蛋白质的细胞外部分和成纤维细胞生长因子之间的相互作用启动信号级联,影响有丝分裂和分化。FGFR-2 beta IIIc 充当酸性、碱性和/或角质形成细胞生长因子的高亲和力受体,具体取决于亚型。该基因的突变与各种颅缝早闭综合征有关,包括克鲁宗综合征、普法伊弗综合征、阿佩尔综合征、杰克逊-韦斯综合征、比尔-史蒂文森皮回综合征、萨斯雷-乔岑综合征和其他综合征性颅缝早闭。已鉴定出编码不同亚型的多个选择性剪接转录物变体,突出了该基因表达的复杂性和多样性。该基因广泛表达于多种组织,包括皮肤和甲状腺。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

NP_001138387 (R22-E288)

基因 ID
蛋白结构
N-term
FGFR-2 beta IIIc (R22-E288)
Accession # NP_001138387
His
C-term
同用名
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
分子量

Approximately 31.2 kDa.

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FGFR-2 beta IIIc Protein, Human (267a.a, HEK293, His)
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