1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens
  3. Interleukin & Receptors T Cell CD Proteins B Cell CD Proteins NK Cell CD Proteins
  4. IL-2 Receptor CD25/IL-2R alpha
  5. IL-2R alpha
  6. IL-2R alpha 蛋白, Human (HEK293, Fc)

IL-2R alpha 蛋白, Human (HEK293, Fc)

目录号: HY-P70629
COA 产品使用指南

IL-2R alpha 蛋白, Human (HEK293, Fc)是一种由 HEK293 细胞表达的,C 末端有 Fc 片段的重组人IL-2RA。IL-2RA 是白细胞介素-2 受体的一个亚单位,通过调节 IL-2R 对配体的亲和力,在调节 IL-2 介导的反应中发挥着重要作用。

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
10 μg ¥1500 In-stock
50 μg ¥4500 In-stock
100 μg   询价  
250 μg   询价  

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描述

IL-2R alpha Protein, Human (HEK293, Fc), a recombinant human IL-2RA produced in HEK293 cells, has an Fc fragment at the C-terminus. IL-2RA is a subunit of interleukin-2 receptor, plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand[1].

研究背景

IL-2 binds with high affinity to a receptor consisting of three subunits: IL-2Rα (CD25), IL-2Rβ (CD122) and γc (CD132). Alpha subunit plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand. Then, two β and γ subunits initiate the signal transduction process via cytoplasmic tails[1].

生物活性

10 μg/mL (100 μL/well) of immobilized Human IL-2RA-Fc can bind Human IL-2-His with an ED50 value of 0.46 μg/mL.

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P01589(E22-C213)

基因 ID

3559  [NCBI]

同用名
IL-2R alpha; IL-2RA; IL-2 R alpha; Interleukin-2 receptor subunit alpha; CD25; p55; TAC antigen; IL2-RA; IL-2R subunit alpha; IL-2-RA; IL-2 receptor subunit alpha
氨基酸序列

ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSC

分子量

60-80 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

Lyophilized powder.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

Reconstitute at 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-2R alpha Protein, Human (HEK293, Fc)
目录号:
HY-P70629
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