1. Immunology/Inflammation
  2. Interleukin Related
  3. Nemvaleukin alfa

Nemvaleukin alfa  (Synonyms: ALKS 4230; RDB-1450)

目录号: HY-P99752 纯度: 98.90%

Nemvaleukin alfa (ALKS 4230) 是一种 IL-2 融合蛋白,可选择性结合中等亲和力 IL-2R。Nemvaleukin alfa 是 NK 和效应 T 细胞的激活剂。Nemvaleukin alfa 可用于癌症研究。

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Nemvaleukin alfa Chemical Structure

Nemvaleukin alfa Chemical Structure

CAS No. : 2315268-27-8

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1 mg ¥5000
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Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].

(In Vitro)

Nemvaleukin alfa 激活食蟹猴和人类样本的淋巴细胞亚群,EC50s 为 0.45-2.2 nM[2]
Nemvaleukin alfa (0-100 nM,30 分钟) 诱导人细胞 (HH 细胞) 上的中等亲和力 IL-2R 的激活[3]
Nemvaleukin alfa (0-100 nM,30 分钟) 在 NK 细胞中诱导 pSTAT5,EC50 为 0.45 nM[3]
Nemvaleukin alfa (0.5 nM,5 天) 诱导从人外周血中分离的效应淋巴细胞的激活[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

Nemvaleukin alfa (6 mg/kg,皮下注射,每 4 天一次) 抑制小鼠 SCLC 肿瘤的生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCLC orthotopic model[1]
Dosage: 6 mg/kg
Administration: s.c., every 4 days
Result: Delayed tumor growth and prolonged survival.
Animal Model: Male cynomolgus monkeys (PK Assay)[2]
Dosage: 0.3 or 1 mg/kg
Administration: i.v. or s.c.
Result: Pharmacokinetic profile of Nemvaleukin alfa.
Dose Route dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h)
i.v. 0.3 6119 0.083 49.5
s.c. 0.3 549 8 61.9
s.c. 1 1035 8 37.3
Clinical Trial



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纯度 & 产品资料

纯度: 98.90%


Nemvaleukin alfa 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


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