2. Immunology/Inflammation
  3. Interleukin Related
  4. Nemvaleukin alfa

Nemvaleukin alfa  (Synonyms: ALKS 4230; RDB-1450)

目录号: HY-P99752 纯度: 99.50%
COA

摩尔计算器

Nemvaleukin alfa (ALKS 4230) 是一种 IL-2 融合蛋白，可选择性结合中等亲和力 IL-2R。Nemvaleukin alfa 是 NK 和效应 T 细胞的激活剂。Nemvaleukin alfa 可用于癌症研究。

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Nemvaleukin alfa Chemical Structure

Nemvaleukin alfa Chemical Structure

CAS No. : 2315268-27-8

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规格 价格 是否有货 数量
500 μg ￥3100
In-stock
1 mg ￥5000
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Nemvaleukin alfa 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].

体外研究
(In Vitro)

Nemvaleukin alfa 激活食蟹猴和人类样本的淋巴细胞亚群，EC50s 为 0.45-2.2 nM[2]。
Nemvaleukin alfa (0-100 nM，30 分钟) 诱导人细胞 (HH 细胞) 上的中等亲和力 IL-2R 的激活[3]。
Nemvaleukin alfa (0-100 nM，30 分钟) 在 NK 细胞中诱导 pSTAT5，EC50 为 0.45 nM[3]。
Nemvaleukin alfa (0.5 nM，5 天) 诱导从人外周血中分离的效应淋巴细胞的激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nemvaleukin alfa 相关抗体:
体内研究
(In Vivo)

Nemvaleukin alfa (6 mg/kg，皮下注射，每 4 天一次) 抑制小鼠 SCLC 肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCLC orthotopic model[1]
Dosage: 6 mg/kg
Administration: s.c., every 4 days
Result: Delayed tumor growth and prolonged survival.
Animal Model: Male cynomolgus monkeys (PK Assay)[2]
Dosage: 0.3 or 1 mg/kg
Administration: i.v. or s.c.
Result: Pharmacokinetic profile of Nemvaleukin alfa.
Dose Route dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h)
i.v. 0.3 6119 0.083 49.5
s.c. 0.3 549 8 61.9
s.c. 1 1035 8 37.3
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.50%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Nemvaleukin alfa 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemvaleukin alfa2315268-27-8ALKS 4230 RDB-1450ALKS4230ALKS-4230RDB1450RDB 1450RDB-1450Interleukin RelatedILCancerNKeffector T cellIL-2RIL-2intermediate-affinityInhibitorinhibitorinhibit

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