SOST 蛋白, Human (Biotinylated, HEK293, His-Avi)

SOST proteins act as potent inhibitors of bone growth by effectively inhibiting Wnt signaling and subsequent bone formation. SOST exerts its inhibitory effect by interacting with key Wnt pathway components, including LRP4, LRP5, and LRP6. SOST Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SOST protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of SOST Protein, Human (Biotinylated, HEK293, His-Avi) is 190 a.a., with molecular weight of 30-40 kDa.

SOST 蛋白通过有效抑制 Wnt 信号传导和随后的骨形成，充当骨生长的有效负调节因子。SOST 通过与 Wnt 通路的关键成分（包括 LRP4、LRP5 和 LRP6）相互作用，发挥其抑制作用。值得注意的是，它与 LRP4 的相互作用（通过胞外结构域介导）有助于抑制 Wnt 信号传导，而与 LRP5 的相互作用（特别是通过前两个 YWTD-EGF 重复结构域）有助于抑制 Wnt 介导的信号传导。这些分子相互作用强调了 SOST 在调节控制骨骼发育的复杂信号级联中的关键作用，提供维持骨骼稳态的重要调节机制。

Immobilized Anti-SOST Antibody at 0.5 μg/mL (100 μL/well) on the plate. Dose response curve for Biotinylated Human SOST, His Tag with the EC₅₀ of ≤3.9 ng/mL determined by ELISA.

Human

HEK293

N-His;N-Avi

Q9BQB4-1 (Q24-Y213)

50964  [NCBI]

QGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY

30-40 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.