1. 重组蛋白
  2. Enzymes & Regulators
  3. Isomerases (EC 5)
  4. TSLPR 蛋白, Mouse (HEK293, Fc)

TSLPR 蛋白, Mouse (HEK293, Fc)

目录号: HY-P70823
COA 产品使用指南

Cytokine receptor-like factor 2 (Crlf2),也称为胸腺基质淋巴细胞生成素 (TSLP) 受体,是 TSLP 的受体。Crlf2 可以与 TSLP 和 IL7RA 形成功能复合物,并且 Crlf2 的过度表达会通过激活 JAK-STAT 途径刺激细胞增殖。Crlf2 的表达通常在 B 祖细胞急性淋巴细胞白血病 (B-ALL) 群体中上调和突变。TSLPR 蛋白, Mouse (HEK293, Fc) 是重组的 TSLPR 蛋白,由 HEK293 表达,带有 C-hFc 标签。TSLPR 蛋白, Mouse (HEK293, Fc) 全长 214 个氨基酸,分子量为 62-88 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥1500 In-stock
50 μg ¥4200 In-stock
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Cytokine receptor-like factor 2 (Crlf2), also known as thymic stromal lymphopoietin (TSLP) receptor, is a receptor for TSLP. Crlf2 can forms a functional complex with TSLP and IL7RA, and overexpression of Crlf2 stimulates cell proliferation through activation of the JAK-STAT pathway. The expression of Crlf2 usually upregulates and mutated in populations of B-progenitor acute lymphoblastic leukemia (B-ALL)[1][2]. TSLPR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TSLPR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TSLPR Protein, Mouse (HEK293, Fc) is 214 a.a., with molecular weight of 62-88 kDa.

研究背景

细胞因子受体样因子 2 (Crlf2) 也称为胸腺基质淋巴细胞生成素 (TSLP) 受体,是胸腺基质淋巴细胞生成素 (TSLP) 的受体。Crlf2 可以与 TSLP 和 IL7RA 形成功能复合物,Crlf2 的过度表达会通过激活 JAK-STAT 通路 (STAT3 和 STAT5) 刺激细胞增殖。Crlf2 通常在 B 祖细胞急性淋巴细胞白血病 (B-ALL) 群体中上调和突变[1][2]

生物活性

Mouse TSLP R-Fc(Cat#CK37) on Protein A Biosensor can bind Human TSLP with an affinity constant of 67.3 nM.

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

AAH23788.1 (A20-L233)

基因 ID

57914  [NCBI]

蛋白结构
N-term
TSLPR (A20-L233)
Accession # AAH23788.1
hFc
C-term
同用名
CRL2; CRLF2; CRL2 cytokine receptor; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR
氨基酸序列

AAAVTSRGDVTVVCHDLETVEVTWGSGPDHHSANLSLEFRYGTGALQPCPRYFLSGAGVTSGCILPAARAGLLELALRDGGGAMVFKARQRASAWLKPRPPWNVTLLWTPDGDVTVSWPAHSYLGLDYEVQHRESNDDEDAWQTTSGPCCDLTVGGLDPARCYDFRVRASPRAAHYGLEAQPSEWTAVTRLSGAASAASCTASPAPSPALAPPL

分子量

62-88 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

TSLPR Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
TSLPR Protein, Mouse (HEK293, Fc)
目录号:
HY-P70823
需求量: