Inosine-5'-diphosphate  (Synonyms: IDP; Inosine-5'-diphosphoric acid)

Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research^[1][2][3].

Inosine-5'-diphosphate (250 mg/kg; 口服; 单剂量) 可增加小鼠的游泳时间，但对力量耐力无显著影响。在相同条件下，Inosine-5'-diphosphate 提高了热室实验中动物的存活率^[1]。
Inosine-5'-diphosphate (50 mg/kg; 口服; 每天1次，持续6天) 增加小鼠游走的时间，而对游泳和跑步的时间无显著影响^[1]。
Inosine-5'-diphosphate (250 mg/kg; 口服; 实验前 1 小时) 对小鼠有明显的 γ 辐照保护作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

428.19

C₁₀H₁₄N₄O₁₁P₂

86-04-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sengupta P, et al. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Biochim Biophys Acta Gen Subj. 2020 Sep;1864(9):129649.

  [2]. Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.

  [3]. Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.