2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Influenza Virus
  4. RNA polymerase-IN-4

RNA polymerase-IN-4 是一种 RNA 聚合酶 (RNA polymerase) 抑制剂，其 EC50 值为 22.81 nM。RNA polymerase-IN-4 具有强效的抗流感病毒活性 (EC50 值为 3.76 nM) 和相对较低的细胞毒性 (CC50 值为 29.91 μM)。RNA polymerase-IN-4 可用于感染相关研究，如流感病毒感染。

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RNA polymerase-IN-4

RNA polymerase-IN-4 Chemical Structure

CAS No. : 3040910-48-0

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RNA polymerase-IN-4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection[1].

体内研究
(In Vivo)

RNA polymerase-IN-4 (Compound (S,S)-5a) (5-10 mg/kg，静脉注射，感染后第 2 天起每天两次) 能显著缓解感染甲型流感 A/WSN/33 (H1N1) 的 BALB/c 小鼠的体重下降，并降低其肺组织病毒载量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice infected with influenza A/WSN/33 (H1N1)[1]
Dosage: 5 and 10 mg/kg
Administration: Intravenously injection, twice a day from day 2 post-infection
Result: Alleviated weight loss and reduced lung tissue viral load.
Showed no obvious abnormal toxicity.
分子量

537.58

Formula

C28H25F2N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RNA polymerase-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

RNA polymerase-IN-43040910-48-0DNA/RNA SynthesisInfluenza VirusInfluenzaRNA polymeraseinfectionA/WSN/33 (H1N1)virusInhibitorinhibitorinhibit

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