2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. HDAC Apoptosis
  4. Romidepsin

Romidepsin  (Synonyms: FK 228; FR 901228; NSC 630176)

目录号: HY-15149G
产品使用指南 技术支持

Romidepsin (GMP) (FK 228 (GMP)) 是 GMP 级别的 Romidepsin (HY-15149)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Romidepsin (FK 228) 是具有抗肿瘤活性的组蛋白去乙酰化酶 (HDAC) 抑制剂，抑制 HDAC1，HDAC2，HDAC4 和 HDAC6，IC50 值分别为 36 nM，47 nM，510 nM 和 1.4 μM。Romidepsin (FK 228) 由紫色杆菌产生，诱导 G2/M 细胞周期阻滞和凋亡 (apoptosis)。

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Romidepsin Chemical Structure

Romidepsin Chemical Structure

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Romidepsin 相关抗体

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2].

体外研究
(In Vitro)

Romidepsin (GMP) (0-72 hours；0 -80 nM) 以剂量依赖性方式抑制 HCC 细胞增殖[2]。
Romidepsin (GMP) (0-48 hours；0-60 nM) 导致在 HCC 细胞中以时间和剂量依赖性方式诱导 G2/M 期细胞周期停滞[2]。
Romidepsin (GMP) (0-48 小时；0-60 nM) 在 HCC 细胞中促进细胞凋亡，增加 c-caspase-3、c-caspase-9 和 c-PARP 蛋白的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Romidepsin 相关抗体:

Cell Proliferation Assay[2]

Cell Line: HCC cells
Concentration: 0 nM; 10 nM; 20 nM; 30 nM; 40 nM; 50 nM; 60 nM; 70 nM; 80 nM
Incubation Time: 0 hours; 12 hours; 24 hours; 48 hours; 72 hours
Result: Inhibited HCC cells proliferation.

Cell Cycle Analysis[2]

Cell Line: HCC cells
Concentration: 0 nM; 15 nM; 30 nM; 60 nM
Incubation Time: 12 hours; 24 hours; 48 hours
Result: Caused a G2/M arrest.

Western Blot Analysis[2]

Cell Line: HCC cells
Concentration: 0 nM; 15 nM; 30 nM; 60 nM
Incubation Time: 12 hours; 24 hours; 48 hours
Result: Increaesd c-caspase-3, c-caspase-9, and c-PARP expression in HCC cells.
体内研究
(In Vivo)

Romidepsin (GMP) (腹腔注射；0.5 和 1 mg/kg；每 3 天一次；21 天) 抑制肿瘤生长，显示 p-cdc25C、ki67、c-caspase-3 和 c-PARP 的高表达，以及降低肿瘤中 Ki-67 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with Huh7 cells[2]
Dosage: 0.5 and 1 mg/kg
Administration: Intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days
Result: Suppressed tumor growth in mouse xenograft models.
分子量

540.70

Formula

C24H36N4O6S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Romidepsin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romidepsin (GMP)FK 228 (GMP)FR 901228 (GMP)NSC 630176 (GMP)HDACApoptosisHistone deacetylasesInhibitorinhibitorinhibit

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