2. Inhibitory Antibodies
  3. Rosmantuzumab

Rosmantuzumab  (Synonyms: OMP-131R10)

目录号: HY-P99401 纯度: 95.00%
COA

摩尔计算器

Rosmantuzumab (OMP-131R10) 是一种抗 R-spondin 3 (RSPO3) 人源化单克隆抗体。Rosmantuzumab 可用于晚期复发难治性实体瘤的研究。

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Rosmantuzumab Chemical Structure

Rosmantuzumab Chemical Structure

CAS No. : 1684393-04-1

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
In-stock
10 mg   询价  
50 mg   询价  

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Rosmantuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors[1].

体内研究
(In Vivo)

Rosmantuzumab (25 mg/kg；腹腔注射，每周一次，持续 4 周) 显著保护动物免于发生肝纤维化[1]。
Rosmantuzumab (25mg /kg；腹腔注射，每两周一次，持续 6 周) 在博莱霉素诱导的肺纤维化小鼠模型中，显著抑制皮肤厚度、胶原沉积和 α-SMA 阳性细胞数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57B1/6J CCl4 liver fibrosis mouse models[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection; 25 mg/kg, once a week for 4 weeks
Result: Significantly decreased collagen I and collagen III mRNAs, and inhibits β-catenin cytoplasmic and nuclear translocation.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosmantuzumab1684393-04-1OMP-131R10OthersmAbfibrosisbleomycinmousecancerInhibitorinhibitorinhibit

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