2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. RP-69758

RP-69758 是一种强效且选择性的非肽类胆囊收缩素B (CCKB)/胃泌素受体 (gastrin receptor) 拮抗剂。RP-69758 对 CCKB 受体的选择性比 CCKA 受体高 200 倍以上。RP-69758 可拮抗 CCK-8 诱导的大鼠海马切片神经元放电。RP-69758 可抑制 Pentagastrin (HY-A0261) 诱导的大鼠胃酸分泌。RP-69758 可用于神经系统疾病和胃肠道疾病的研究。

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RP-69758

RP-69758 Chemical Structure

CAS No. : 138562-23-9

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RP-69758 相关抗体

Top Publications Citing Use of Products

查看 Cholecystokinin Receptor 亚型特异性产品:

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CCKAR CCKBR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB)/gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261)-induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research[1].

体外研究
(In Vitro)

RP-69758 对 CCKB 受体和胃泌素受体均表现出高亲和力，其对 CCKB 受体的亲和力 (Ki) 为：豚鼠大脑皮层 9.0 nM、大鼠大脑皮层 4.3 nM、小鼠全脑 5.0 nM；对胃泌素受体的亲和力 (Ki) 为：豚鼠胃腺 3.7 nM，此外，其在离体实验中抑制小鼠脑内的 CCK 结合，IC50 为 17.6 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RP-69758 相关抗体:
分子量

474.51

Formula

C26H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RP-69758 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RP-69758138562-23-9RP69758RP 69758Cholecystokinin ReceptorCCK Receptorcholecystokinin-Bgastrin receptorneuronal firinggastric acid secretionneurological disordersgastrointestinal diseaseInhibitorinhibitorinhibit

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目录号：
HY-116260
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