2. Cytoskeleton
  3. Integrin
  4. SC-68448

SC-68448 (S 448) 是一种选择性 αvβ3 拮抗剂 (IC50 = 1 nM)。SC-68448 抑制 αvβ3 介导的内皮细胞增殖。SC-68448 降低 NHBE 细胞中 αvβ6 的总水平。SC-68448 在大鼠角膜新生模型中抑制了血管生成。SC-68448 在鼠莱迪希细胞肿瘤模型中抑制肿瘤生长并完全阻止高钙血症的发展。SC-68448 可用于高钙血症等心脑血管疾病和睾丸间质细胞瘤等癌症的研究。

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SC-68448

SC-68448 Chemical Structure

CAS No. : 188804-07-1

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SC-68448 相关抗体

Top Publications Citing Use of Products

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM). SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors[1][2].

分子量

452.29

Formula

C19H19Cl2N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SC-68448 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-68448188804-07-1S 448SC68448SC 68448S448S-448Integrinαvβ3 peptide kinase antagonistNHBE cellsrat corneal neoplasia modelLedich cell tumor modelInhibitorinhibitorinhibit

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