Scopolamine-d₃ hydrobromide hydrate  (Synonyms: 东莨菪碱-d₃ 氢溴酸盐水合物)

Scopolamine-d₃ Hydrobromide Hydrate is the deuterium labeled Scopolamine Hydrobromide Hydrate. Scopolamine (Hyoscine) is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine competitively antagonizes 5-HT₃ receptors with an IC₅₀ of 2.09 μM. Scopolamine can induce cognitive and memory deficits in animals. Scopolamine can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc^{[1][2][3][4][5]}.

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

405.30

C₁₇H₂₁D₃BrNO₅

152612-85-6

东莨菪碱-d₃ 氢溴酸盐水合物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lochner M, et al. The muscarinic antagonists Scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology. 2016 Sep;108:220-8.  [Content Brief]

  [2]. O ET, et al. COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE. Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):136-141.  [Content Brief]

  [3]. Pattanashetti LA, et al. Evaluation of neuroprotective effect of Quercetin with Donepezil in Scopolamine-induced amnesia in rats. Indian J Pharmacol. 2017 Jan-Feb;49(1):60-64.  [Content Brief]

  [4]. Yadang FSA, et al. Scopolamine-Induced Memory Impairment in Mice: Neuroprotective Effects of Carissa edulis (Forssk.) Valh (Apocynaceae) Aqueous Extract. Int J Alzheimers Dis. 2020 Aug 31;2020:6372059.  [Content Brief]

  [5]. Klinkenberg I, et al. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev. 2010 Jul;34(8):1307-50.  [Content Brief]