1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Sergliflozin etabonate

Sergliflozin etabonate  (Synonyms: GW-869682X)

目录号: HY-12611
产品使用指南

Sergliflozin etabonate (GW-869682X) 是一种有效的口服活性钠葡萄糖协同转运蛋白 (SGLT2) (SGLT2) 抑制剂。Sergliflozin etabonate 具有抗糖尿病和抗高血糖作用。Sergliflozin etabonate 显着降低糖尿病小鼠的非空腹血糖水平。Sergliflozin etabonate 具有用于糖尿病研究的潜力。

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Sergliflozin etabonate Chemical Structure

Sergliflozin etabonate Chemical Structure

CAS No. : 408504-26-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sergliflozin etabonate (GW-869682X) is a potent and orally active sodium glucose cotransporter (SGLT2) inhibitor. Sergliflozin etabonate shows antidiabetic and antihyperglycemic effects. Sergliflozin etabonate significantly reduces non-fasting blood glucose levels in diabetic mice. Sergliflozin etabonate has the potential for the research of diabetes[1].

IC50 & Target[1]

SGLT2

 

体内研究
(In Vivo)

Sergliflozin etabonate (1、3、10、30 mg/kg;口服;一次) 以剂量依赖性方式显着降低 KK-Ay 小鼠的非空腹血糖水平[1]
Sergliflozin etabonate (1.7、8.4、45.7 mg/kg饲料含有 0.001、0.005 和 0.025% sergliflozin etabonate;进食;每天服用,持续 9 周) 以剂量依赖的方式降低非空腹血糖水平并降低肝脏中的甘油三酯含量 在 KK-Ay 小鼠中[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 14 weeks, Female KK-Ay mice[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: Oral; once
Result: Significantly reduced non-fasting blood glucose level with the reduction in blood glucose level at 2 h post dosing in the 1 mg/kg group, 3 mg/kg group, 10 mg/kg group, and 30 mg/kg group was 12, 15, 28, and 39%, respectively.
Animal Model: 4 weeks, Female KK-Ay mice[1]
Dosage: 1.7, 8.4, 45.7 mg/kg in the 0.001, 0.005, and 0.025% sergliflozin etabonate
Administration: Fed, daily for 9 weeks
Result: Reduced non-fasting blood glucose level and decreased triglyceride content in the liver in a dose-dependent manner in diabetic control KK-Ay mice.
分子量

448.46

Formula

C23H28O9

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Sergliflozin etabonate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sergliflozin etabonate
目录号:
HY-12611
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