2. Metabolic Enzyme/Protease
  3. PAI-1
  4. SK-216

SK-216 是一种纤溶酶原激活剂抑制剂-1 (PAI-1) 抑制剂，可作为人骨肉瘤抗转移剂，抑制人骨肉瘤肺转移。

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SK-216 Chemical Structure

SK-216 Chemical Structure

CAS No. : 654080-03-2

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规格 价格 是否有货
5 mg ￥2142
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SK-216 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1].

体外研究
(In Vitro)

SK-216 (0-50 μM, 48 h) 可以以剂量依赖的方式抑制 143B 细胞的侵袭，但不影响细胞增殖和迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SK-216 相关抗体:

Western Blot Analysis [1]

Cell Line: human osteosarcoma cell line 143B
Concentration: 0, 25, 50 μM
Incubation Time: 48 h
Result: Inhibited PAI-1 expression by 40% at concentrations of 25 and 50 μM，and lead to a significantly lower ratio of cell-invaded wells/total wells.
Inhibited MMP-13 secretion in 143B cells.
体内研究
(In Vivo)

SK-216（i.p.，6.6 μg / 200 μL in PBS，每 3 天一次）在 143B-Luc 细胞感染雄性无胸腺裸鼠模型中，可以抑制人骨肉瘤细胞的肺转移，但不能抑制原发灶的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6-week-old male athymic nude mice with 143B-Luc cell[1]
Dosage: 6.6 μg/200 μL in PBS
Administration: i.p., once every 3 days
Result: Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice.
分子量

533.52

Formula

C29H29NNa2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SK-216 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-216654080-03-2SK216SK 216PAI-1Plasminogen activator inhibitor-1plasminogenosteosarcomametastasisInhibitorinhibitorinhibit

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目录号：
HY-122714
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