2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Interleukin Related STAT
  4. SMI-10B13

SMI-10B13 是一种制瘤素 M (OSM) 抑制剂，其解离常数 (KD) 值为 6.6 μM。SMI-10B13 可抑制 T47D 和 MCF-7 细胞系中 OSM 介导的 STAT3 磷酸化，IC50 值分别为 136 nM 和 164 nM。SMI-10B13 在人乳腺癌小鼠模型中显示出抗肿瘤作用。

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SMI-10B13

SMI-10B13 Chemical Structure

CAS No. : 2502294-68-8

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SMI-10B13 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].

体外研究
(In Vitro)

SMI-10B13 (100 μM) 几乎能完全抑制 gp130 与固定化 OSM 的结合能力[1]。
SMI-10B13 (10 μM, 30 mins) 可降低 T47D 乳腺癌细胞中 OSM 介导的 pSTAT3 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SMI-10B13 相关抗体:
体内研究
(In Vivo)

SMI-10B13 (50 mg/kg，腹腔注射，肿瘤细胞注射前 12 小时) 在人乳腺癌异种移植小鼠模型中可抑制肿瘤生长并延长生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ER+ breast cancer xenograft mice models (7-8 weeks, athymic nu/nu mice)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection, 12 h before tumor cell injection and 3 times q week thereafter
Result: Showed a significant reduction in tumor growth.
Displayed minimal to no cytotoxicity at high concentrations.
Prevented metastasis and increased survival.
分子量

368.38

Formula

C23H16N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMI-10B13 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMI-10B132502294-68-8Interleukin RelatedSTATILOncostatin MSTAT3T47DMCF-7Breast cancerInhibitorinhibitorinhibit

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目录号：
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