2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. SP/W 5186

SP/W-5186 是一种含有半胱氨酸结构的一氧化氮 (NO) 供体剂。SP/W-5186 可改善心功能与减少心肌损伤、保护血管内皮功能并抑制炎症与氧化应激。SP/W-5186 具有抑制过氧亚硝酸盐 (ONOO⁻) 诱导的氧化损伤的能力。SP/W-5186 可用于心肌缺血再灌注损伤的研究。

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SP/W 5186

SP/W 5186 Chemical Structure

CAS No. : 139146-65-9

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SP/W 5186 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

SP/W-5186 is a nitric oxide (NO) donor agent containing a cysteine structure. SP/W-5186 can improve cardiac function, reduce myocardial damage, protect vascular endothelial function and inhibit inflammation and oxidative stress. SP/W-5186 has the ability to inhibit oxidative damage induced by peroxynitrite (ONOO⁻). SP/W-5186 can be used in the research of myocardial ischemia-reperfusion injury[1][2].

体内研究
(In Vivo)

SP/W-5186 (0.3-1 μmol/kg, i.v., 单次给药) 能够释放一氧化氮，显著保护兔子的心肌组织免受再灌注损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Myocardial ischemia-reperfusion injury model established in adult male New Zealand white rabbits (2.8-3.5 kg)[1]
Dosage: 0.3 and 1 μmol/kg
Administration: Intravenous injection (i.v.), single dose
Result: Significantly improved the recovery of cardiac function.
Effectively alleviated myocardial cell damage.
Effectively inhibited the aggregation and infiltration of neutrophils in the myocardium, as well as the MDA content and platelet aggregation in the myocardial tissue.
Significantly improved the vasodilatory response of blood vessels to ACh, indicating that it effectively protected the endothelial function.
分子量

393.41

Formula

C14H23N3O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

SP/W 5186 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP/W 5186139146-65-9Endogenous MetabolitePMNpolymorphonuclear leukocyteEDRFendothelium-derived relaxing factorNOnitric oxideNTGnitroglycerinLVleft ventricular or left ventricleInhibitorinhibitorinhibit

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目录号：
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