1. Metabolic Enzyme/Protease
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  3. ssPalmE-P4-C2

ssPalmE-P4-C2 是一种 SS 可裂解且 pH 敏感型类脂质材料 (ssPalm),其带有维生素 E 支架。ssPalmE-P4-C2 可提高针对 FVII 的基因敲低活性,ED50 为 0.5 mg/kg。ssPalmE-P4-C2 可用于合成脂质纳米颗粒 (LNPs),以递送 siRNA 至肝细胞。ssPalmE-P4-C2 可用于血脂异常、乙型/丙型肝炎感染和转甲状腺素蛋白淀粉样变性的 RNA 疗法研究。

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ssPalmE-P4-C2

ssPalmE-P4-C2 Chemical Structure

CAS No. : 2247153-41-7

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  • 生物活性

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生物活性

ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research[1].

分子量

1402.15

Formula

C84H140N2O10S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ssPalmE-P4-C2
目录号:
HY-176518
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