1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Sulfo-ara-F-NMN

Sulfo-ara-F-NMN (Synonyms: CZ-48)

目录号: HY-129522
产品使用指南

Sulfo-ara-F-NMN (CZ-48) 是一种烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 选择性激活 SARM1,但抑制 CD38 (IC50 约为 10 μM)。Sulfo-ara-F-NMN 诱导细胞内环状 ADP-核糖 (cADPR) 的产生。

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Sulfo-ara-F-NMN Chemical Structure

Sulfo-ara-F-NMN Chemical Structure

CAS No. : 1374663-29-2

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Description

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].

In Vitro

Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].

Molecular Weight

352.28

Formula

C₁₁H₁₄FN₂O₆PS

CAS No.

1374663-29-2

SMILES

O=C(N)C1=CC=C[N+]([C@@H]2O[C@H](COP([O-])(O)=S)[C@@H](O)[C@@H]2F)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
C1   V1   C2   V2

Keywords:

Sulfo-ara-F-NMNCZ-48CZ48CZ 48Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Sulfo-ara-F-NMN
目录号:
HY-129522
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