2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. Tiludronate disodium

Tiludronate disodium  (Synonyms: Tiludronic acid disodium)

目录号: HY-A0213A 纯度: 99.84%
COA 产品使用指南

摩尔计算器

Tiludronate (Tiludronic Acid) disodium 是一种口服活性双膦酸盐，可以起到骨调节作用。Tiludronate disodium 用于代谢性骨疾病的研究。Tiludronate disodium 是破骨细胞空泡H(+)-ATP酶的有效抑制剂。

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Tiludronate disodium Chemical Structure

Tiludronate disodium Chemical Structure

CAS No. : 149845-07-8

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规格 价格 是否有货 数量
1 mg ￥600
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5 mg ￥1800
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10 mg ￥3000
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Customer Review

Other Forms of Tiludronate disodium:

Tiludronate disodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

体外研究
(In Vitro)

The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tiludronate disodium 相关抗体:
体内研究
(In Vivo)

Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

362.57

Formula

C7H7ClNa2O6P2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 62.5 mg/mL (172.38 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7581 mL 13.7904 mL 27.5809 mL
5 mM 0.5516 mL 2.7581 mL 5.5162 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.84%

COA (197 KB) HNMR (262 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

Tiludronate disodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7581 mL 13.7904 mL 27.5809 mL 68.9522 mL
5 mM 0.5516 mL 2.7581 mL 5.5162 mL 13.7904 mL
10 mM 0.2758 mL 1.3790 mL 2.7581 mL 6.8952 mL
15 mM 0.1839 mL 0.9194 mL 1.8387 mL 4.5968 mL
20 mM 0.1379 mL 0.6895 mL 1.3790 mL 3.4476 mL
25 mM 0.1103 mL 0.5516 mL 1.1032 mL 2.7581 mL
30 mM 0.0919 mL 0.4597 mL 0.9194 mL 2.2984 mL
40 mM 0.0690 mL 0.3448 mL 0.6895 mL 1.7238 mL
50 mM 0.0552 mL 0.2758 mL 0.5516 mL 1.3790 mL
60 mM 0.0460 mL 0.2298 mL 0.4597 mL 1.1492 mL
80 mM 0.0345 mL 0.1724 mL 0.3448 mL 0.8619 mL
100 mM 0.0276 mL 0.1379 mL 0.2758 mL 0.6895 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiludronate disodium149845-07-8Tiludronic acid disodiumProton PumporalbisphosphonateinflammatoryV-ATPaseosteoporosisyeastInhibitorinhibitorinhibit

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