2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tipepidine

Tipepidine可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK) 的 IC50 为 7.0 μM。Tipepidine是一种镇咳药，具有抗抑郁样作用。

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Tipepidine Chemical Structure

Tipepidine Chemical Structure

CAS No. : 5169-78-8

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Tipepidine 的其他形式现货产品:

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Tipepidine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

IC50 & Target

IC50: 7.0 μM (dopamine D2 receptor)[1]
体内研究
(In Vivo)

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2]
Dosage: 10, 20 and 40 mg/kg.
Administration: I.p.; 0.5, 5, 23 hours.
Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Clinical Trial
分子量

275.43

Formula

C15H17NS2
CAS 号
性状

固体

颜色

White to light yellow

中文名称

替比啶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tipepidine 相关分类

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Keywords:

Tipepidine5169-78-8替比啶Potassium ChannelKcsAantidepressant-likenon-narcotic antitussivedopamineGIRKInhibitorinhibitorinhibit

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