2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tipepidine

Tipepidine  (Synonyms: 替比啶)

目录号: HY-121685
产品使用指南

摩尔计算器

Tipepidine可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK) 的 IC50 为 7.0 μM。Tipepidine是一种镇咳药，具有抗抑郁样作用。

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Tipepidine Chemical Structure

Tipepidine Chemical Structure

CAS No. : 5169-78-8

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Tipepidine 的其他形式现货产品:

Customer Review

Other Forms of Tipepidine:

Tipepidine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

IC50 & Target

IC50: 7.0 μM (dopamine D2 receptor)[1]
体内研究
(In Vivo)

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2]
Dosage: 10, 20 and 40 mg/kg.
Administration: I.p.; 0.5, 5, 23 hours.
Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Clinical Trial
分子量

275.43

Formula

C15H17NS2
CAS 号
性状

固体

颜色

White to light yellow

中文名称

替比啶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (907.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6307 mL 18.1534 mL 36.3069 mL
5 mM 0.7261 mL 3.6307 mL 7.2614 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Tipepidine 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6307 mL 18.1534 mL 36.3069 mL 90.7672 mL
5 mM 0.7261 mL 3.6307 mL 7.2614 mL 18.1534 mL
10 mM 0.3631 mL 1.8153 mL 3.6307 mL 9.0767 mL
15 mM 0.2420 mL 1.2102 mL 2.4205 mL 6.0511 mL
20 mM 0.1815 mL 0.9077 mL 1.8153 mL 4.5384 mL
25 mM 0.1452 mL 0.7261 mL 1.4523 mL 3.6307 mL
30 mM 0.1210 mL 0.6051 mL 1.2102 mL 3.0256 mL
40 mM 0.0908 mL 0.4538 mL 0.9077 mL 2.2692 mL
50 mM 0.0726 mL 0.3631 mL 0.7261 mL 1.8153 mL
60 mM 0.0605 mL 0.3026 mL 0.6051 mL 1.5128 mL
80 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1346 mL
100 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9077 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tipepidine5169-78-8替比啶Potassium ChannelKcsAantidepressant-likenon-narcotic antitussivedopamineGIRKInhibitorinhibitorinhibit

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