2. Metabolic Enzyme/Protease Apoptosis
  3. Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis
  4. TPP-IOA

TPP-IOA 是一种 cytochrome c 过氧化物酶抑制剂。TPP-IOA 通过阻止心磷脂氧化和 cytochrome c 释放到细胞质中来抑制细胞凋亡 (apoptosis)。TPP-IOA 干扰分离线粒体的氧化磷酸化 (oxidative phosphorylation)。TPP-IOA 在葡萄糖培养基中抑制 SH-SY5Y 细胞的细胞死亡，但在半乳糖培养基中无此效果。TPP-IOA 引起线粒体去极化和网络碎裂。TPP-IOA 减轻小鼠辐射诱导的死亡。

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TPP-IOA

TPP-IOA Chemical Structure

CAS No. : 1423018-61-4

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TPP-IOA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice[1].

体外研究
(In Vitro)

TPP-IOA (0-10 μM) 通过物理相互作用与细胞色素 c 结合，呈剂量依赖性抑制抗坏血酸介导的cytochrome c 还原，并降低细胞色素c/心磷脂溶液中试卤灵的形成速率[1]。
TPP-IOA (0.5-10 μM) 在分离的线粒体中抑制 resorufin 的形成，在 5 μM 时显著抑制，这是由于其含咪唑的油酸部分[1]。
TPP-IOA (0-10 μM) 抑制每 nmol 细胞色素 c 对过氧化物酶活性和还原活性的 IC50 值分为 0.65 nmol 和 5.28 nmol [1]。
TPP-IOA (0.5-10 μM) 以剂量依赖方式降低大鼠肝线粒体的呼吸控制比率和氧化磷酸化耦合效率[1]。
TPP-IOA (1 μM, 3 h)可降低 SH-SY5Y 细胞的线粒体膜电位，破坏线粒体网状结构，减少线粒体含量，并抑制 FCCP 解偶联呼吸，同时维持基础耗氧量[1]。
TPP-IOA (0.25-5 μM) 在葡萄糖培养基而非半乳糖培养基中抑制 SH-SY5Y 细胞中 H2O2 诱导的总细胞死亡和 caspase-3 活性[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TPP-IOA 相关抗体:

Immunofluorescence[1]

Cell Line: SH-SY5Y cells
Concentration: 1 μM
Incubation Time: 3 h
Result: Showed a less interconnected, more fragmented mitochondrial reticulum.
Increased the absolute number of individual mitochondrial network-like structures in cells.
体内研究
(In Vivo)

TPP-IOA (5 mg/kg，腹腔注射，每日一次，持续 52 天) 对全身暴露于 9.25 Gy 辐射的 C57BL/6NTac 雌性小鼠表现出显著的辐射防护效应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NTac female mice were exposed to total body irradiation to a dose of 9.25 Gy using a cesium source[2].
Dosage: 5 mg/kg
Administration: i.p. daily for 52 days (10 min, 1 h before irradiation or 10 min, 1 h, 5 h 24 h after irradiation)
Result: Showed a strong radiomitigative effect.
分子量

731.78

Formula

C42H56BrN2O2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPP-IOA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPP-IOA1423018-61-4Oxidative PhosphorylationMitochondrial MetabolismApoptosisOxidative phosphorylationCytochrome cPeroxidaseTriphenylphosphoniumInhibitorinhibitorinhibit

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