2. Anti-infection Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Fungal HDAC Apoptosis
  4. Trichostatin C

Trichostatin C 是一种组蛋白脱乙酰酶 (HDAC) 抑制剂，可诱导细胞凋亡 (apoptosis) 并将细胞周期阻滞在 G2/M 期，对肺癌和膀胱尿路上皮癌具有抗癌活性。Trichostatin C 诱导 Friend 白血病细胞分化。 Trichostatin C 具有抗真菌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Trichostatin C Chemical Structure

Trichostatin C Chemical Structure

CAS No. : 68676-88-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Trichostatin C 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].

IC50 & Target

HDAC1

 

HDAC6

 

体外研究
(In Vitro)

Trichostatin C (0-100 μM) 对 HDAC1 和 HDAC6 表现出抑制活性，抑制癌细胞 A549、J82 和 SK-BR-3 的增殖，IC 50 分别为 6.24，4.16 和 0.6 μM[1]。
Trichostatin C (0-10 μM) 通过激活 caspase 3 和 caspase 7 诱导 J82 细胞凋亡 (apoptosis)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trichostatin C 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549, J82 and SK-BR-3
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibits proliferations of A549, J82 and SK-BR-3.

Western Blot Analysis[1]

Cell Line: J82
Concentration: 20-80 μM
Incubation Time: 24 h
Result: Induced acetylation of α-Tubulin and Histone 3 (markers of HDAC1 and HDAC6 inhibition).

Apoptosis Analysis[1]

Cell Line: J-82
Concentration: 0.1-10 μM
Incubation Time: 48 h
Result: Activated 23.1, 61.7 and 62.3% caspase 3/7 at 0.1 μM, 1 μM and 10 μM.
分子量

464.51

Formula

C23H32N2O8
CAS 号
结构分类
初始来源

Streptomyces sp. RK98-A74
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trichostatin C 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trichostatin C68676-88-0FungalHDACApoptosisHistone deacetylasesLeukemialung cancerurothelial bladder cancerbreast cancerA549J82SK-BR-3Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Trichostatin C
目录号：
HY-126566
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z