2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Trimipramine N-oxide

Trimipramine N-oxide 是三环抗抑郁药 trimipramine 的活性代谢物。Trimipramine N-oxide 对人去甲肾上腺素单胺转运体 (hNAT)，血清素 (hSERT)，多巴胺 (hDAT) 和人体有机阳离子转运蛋白 (hOCT1 和 hOCT2) 的 IC50 值分别为 11.7，3.59，9.4，9.35 和 27.4 nM。Trimipramine N-oxid 可用于忧郁和焦虑的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Trimipramine N-oxide Chemical Structure

Trimipramine N-oxide Chemical Structure

CAS No. : 14171-70-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Trimipramine N-oxide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety[1].

IC50 & Target

IC50: 3.59 nM (hSERT), 9.35 nM (hOCT1), 9.4 nM (hDAT), 11.7 nM (hNAT), 27.4 (hOCT2)[1]
体外研究
(In Vitro)

Trimipramine N-oxide (0-30 μM; 48 h) inhibits hNAT, hSERT, hDAT, hOCT1 and hOCT2 in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trimipramine N-oxide 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-30 μM
Incubation Time: 48 hours
Result: Dose-dependently inhibited hNAT, hSERT, hDAT, hOCT1 and hOCT2 with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM in HEK293 cells, respectively.
分子量

310.43

Formula

C20H26N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trimipramine N-oxide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimipramine N-oxide14171-70-1Drug Metaboliteactive metabolitehuman monoamine transporterhuman organic cation transportertrimipramineInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Trimipramine N-oxide
目录号：
HY-147333
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z