2. Cell Cycle/DNA Damage Cytoskeleton PI3K/Akt/mTOR Apoptosis
  3. Microtubule/Tubulin PI3K Akt Apoptosis
  4. Tubulin-IN-55

Tubulin-IN-55 是一种 tubulin 抑制剂。Tubulin-IN-55 可破坏癌细胞中的 PI3K/Akt 信号通路。Tubulin-IN-55 对多种肿瘤细胞 (HeLa、HCT116、4T1、A549、H1299、MDA-MB231) 表现出广谱的抗增殖活性。Tubulin-IN-55 可诱导 G2/M 期阻滞和凋亡 (apoptosis)，并抑制癌细胞的迁移/侵袭。Tubulin-IN-55 在原位自体移植小鼠模型中展现出显著的抗肿瘤功效。Tubulin-IN-55 可用于癌症研究。

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Tubulin-IN-55

Tubulin-IN-55 Chemical Structure

CAS No. : 353258-94-3

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Tubulin-IN-55 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin-IN-55 is a tubulin inhibitor. Tubulin-IN-55 disrupts the PI3K/Akt signaling pathway in cancer cells. Tubulin-IN-55 exerts broad-spectrum anti-proliferative activity against multiple tumor cells (HeLa, HCT116, 4T1, A549, H1299, MDA-MB231). Tubulin-IN-55 induces G2/M phase arrest and apoptosis, and inhibits tumor cell migration/invasion in cancer cells. Tubulin-IN-55 demonstrates potent antitumor efficacy in orthotopic autologous transplantation mice. Tubulin-IN-55 can be used for the study of cancer[1].

体外研究
(In Vitro)

Tubulin-IN-55 (Compound 89) (0.1-10 μM，24 h) 对 HeLa、HCT116 和 4T1 细胞表现出强效的抗增殖活性，其 IC50 值分别为 1.20 μM、4.91 μM、1.13 μM 和 0.65 μM[1]。
Tubulin-IN-55 (0.3-0.9 μM，12-24 h) 对 HeLa、HCT116 和 4T1 细胞表现出抗迁移和抗侵袭作用[1]。
Tubulin-IN-55 (0.3-1.2 μM，24 h) 可诱导 HeLa、HCT116 和 4T1 细胞凋亡及 G2/M 期阻滞[1]。
Tubulin-IN-55 (6.25-100 μM，60 min) 在体外以剂量依赖性方式抑制微管蛋白聚合[1]。
Tubulin-IN-55 (0.3-0.9 μM，24 h) 可下调 HeLa、HCT116 和 4T1 细胞中 PI3K 和 Akt 的磷酸化水平，而不改变总 PI3K 和 Akt 的水平。
Tubulin-IN-55 (0.1-10 μM，24 h) 对 BC-PDO1、BC-PDO2 和 BC-PDO10 (乳腺癌类器官) 表现出抗肿瘤活性，降低类器官活性，其 IC50 值分别为 1.07 μM、0.81 μM 和 0.42 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin-IN-55 相关抗体:

Cell Migration Assay [1]

Cell Line: HeLa, HCT116, and 4T1 cells
Concentration: 0.3, 0.9 μM
Incubation Time: 12, 24 h
Result: Exhibited anti-migratory effects on HeLa, HCT116, and 4T1 cells.
Upregulated epithelial marker E-Cadherin.

Cell Invasion Assay[1]

Cell Line: HeLa, HCT116, and 4T1 cells
Concentration: 0.3, 0.9 μM
Incubation Time: 12, 24 h
Result: Exhibited anti-migratory effects on HeLa, HCT116, and 4T1 cells.
Upregulated epithelial marker E-Cadherin.

Apoptosis Analysis[1]

Cell Line: 0.3, 0.6, 1.2 μM
Concentration: 0.3, 0.9 μM
Incubation Time: 24 h
Result: Induced apoptosis.
Increased the proportion of apoptotic cells.
Upregulated cleaved-PARP and Bax, and downregulated Bcl-2.

Cell Cycle Analysis[1]

Cell Line: 0.3, 0.6, 1.2 μM
Concentration: 0.3, 0.9 μM
Incubation Time: 24 h
Result: Induced G2/M phase arrest.
Upregulated Cyclin B1 and downregulated CDK1 and Cdc25c.
体内研究
(In Vivo)

Tubulin-IN-55 (Compound 89) (10 mg/kg，腹腔注射，每两天一次，持续 4 周) 在 BALB/c 小鼠的原位自体移植模型中表现出显著的抗肿瘤功效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumor cells were implanted into 6-8-week-old BALB/c mice to establish the in vivo tumor model[1]
Dosage: 10 mg/kg
Administration: i.p., once every two days, 4 weeks
Result: Achieved tumor growth inhibition.
Suppressed breast cancer metastasis to the lung.
Reduced the Ki67 expression and PCNA expression in tumor tissues.
Disrupted the microtubule network in tumor tissues.
Showed no significant changes in body weight and major organ (heart, liver, spleen, lung, kidney) weights.
分子量

350.46

Formula

C21H26N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin-IN-55 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin-IN-55353258-94-3Microtubule/TubulinPI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BHeLaHCT1164T1A549H1299MDA-MB231tubulincancerInhibitorinhibitorinhibit

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