2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-61

Tubulin polymerization-IN-61 (Compound 9a) 是一种微管蛋白聚合抑制剂。Tubulin polymerization-IN-61 破坏微管骨架，阻断细胞周期 G2/M 期，诱导细胞凋亡 (Apoptosis)，抑制癌细胞迁移和集落形成。Tubulin polymerization-IN-61 在 in vivo 4T1 异种移植模型中表现出抗肿瘤活性。

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Tubulin polymerization-IN-61

Tubulin polymerization-IN-61 Chemical Structure

CAS No. : 2758114-60-0

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Tubulin polymerization-IN-61 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
32 nM
Compound: 9a
Antiproliferative activity against mouse 4T1 cells measured after 72 hrs by MTT assay
Antiproliferative activity against mouse 4T1 cells measured after 72 hrs by MTT assay
[PMID: 38471357]
A549 IC50
0.045 μM
Compound: 9a
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
[PMID: 38471357]
MCF7 IC50
0.02 μM
Compound: 9a
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 38471357]
MCF7 IC50
0.027 μM
Compound: 17a
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 38996194]
SGC-7901 IC50
0.014 μM
Compound: 9a
Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
[PMID: 38471357]
体外研究
(In Vitro)

Tubulin polymerization-IN-61 对三种人类癌细胞系 (MCF-7、SGC-7901 和 A549) 具有抗增殖活性，IC50 值范围为 14 至 45 nM[1]。
Tubulin polymerization-IN-61 (20-60 nM,24 h) 将 MCF-7 细胞 G2/M 周期比例从 14% 增加至 50%，诱导细胞凋亡，并抑制 MCF-7 细胞迁移和集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-61 相关抗体:
体内研究
(In Vivo)

Tubulin polymerization-IN-61 (5 或 15 mg/kg，静脉注射，每两天一次，持续 2 周) 在 BALB/c 小鼠 4T1 异种移植肿瘤模型中显示出抗肿瘤作用，且毒性可忽略不计[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

407.42

Formula

C22H21N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-61 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-612758114-60-0Microtubule/TubulinApoptosis4T1tumorMCF-7SGC-7901A549Inhibitorinhibitorinhibit

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