2. Membrane Transporter/Ion Channel
  3. URAT1
  4. URAT1-IN-14

URAT1-IN-14 是一种强效且口服有效的尿酸转运蛋白 1 (URAT1) 抑制剂。URAT1-IN-14 在 HEK293 细胞中抑制人 URAT1 的 IC50 值为 0.72 μM。URAT1-IN-14 在 Hep-G2 细胞中表现出低细胞毒性。URAT1-IN-14 在高尿酸血症小鼠模型中显示降尿酸作用。URAT1-IN-14 可用于高尿酸血症和痛风的研究。

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URAT1-IN-14

URAT1-IN-14 Chemical Structure

CAS No. : 2516232-89-4

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URAT1-IN-14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout[1].

体外研究
(In Vitro)

URAT1-IN-14 (Compound 7) (IC50 = 326.5 μM) 对 Hep-G2 细胞的细胞毒性低于Benzbromarone (HY-B1135) (IC50 = 67.21 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

URAT1-IN-14 相关抗体:
体内研究
(In Vivo)

URAT1-IN-14 (Compound 7) (25-100 mg/kg, p.o., 单次剂量或连续 9 天给药) 在亚急性和慢性高尿酸小鼠模型中，显著降低血液中的尿酸水平，其效果与 Benzbromarone 的效果相当[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sub-HUA model induced by uric acid and OP in mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: Oral administration (p.o.), single dose
Result: Significantly lowers the blood uric acid level within 24 hours at the dosage of 100 mg/kg.
The AUC0-24h values treated groups decreased in a dose-dependent manner 6%, 17%, 34%, at the doses of 25, 50 and 100 mg/kg, respectively.
Animal Model: Ch-HUA model induced by purine-rich yeast extraction and OP in mice[1]
Dosage: 25, 50 and 100 mg/kg
Administration: Oral administration (p.o.), for 9 days
Result: Drastically decreased blood uric acid level at the dosage of 50 mg/kg.
分子量

341.42

Formula

C19H19NO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

URAT1-IN-14 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URAT1-IN-142516232-89-4URAT1Urate transporter 1SLC22A12GoutHyperuricemiaBenzomorpholine scaffoldHypouricemic efficacyHEK293 cellshyperuricemia mouse modelInhibitorinhibitorinhibit

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