2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-IN-3

VEGFR-IN-3 (compound 3f) 是 VEGFR 抑制剂。VEGFR-IN-3 抑制 OVCAR-4 和 MDA-MB-468 癌细胞的生长，其 IC50 值分别为 0.29 和 0.35 μM。VEGFR-IN-3 可用于癌症的研究。

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VEGFR-IN-3 Chemical Structure

VEGFR-IN-3 Chemical Structure

CAS No. : 2874264-13-6

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VEGFR-IN-3 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.29 μM (OVCAR-4), 0.35 μM (MDA-MB-468), 25.9 μM (MCF-10A)[1]
体外研究
(In Vitro)

VEGFR-IN-3 (10 μM; 60 min) inhibits a variety of cancer cell lines growth[1].
VEGFR-IN-3 (0-100 μM; 72 h) shows cytotoxic activities against MDA-MB-468 and OVCAR-4 cancer cell lines[1].
VEGFR-IN-3 (0.29-0.35 μM; 2.5 h) decreases the concentration of VEGF in OVCAR-4 and MDA-MB-468 cell lines[1].
VEGFR-IN-3 (0.29 μM; 48 h) increases levels of ERK1 and ERK2, activates ERK1 and ERK2 phosphorylation[1].
VEGFR-IN-3 (0.29 μM; 24 h) affects cell cycle and induces apoptosis of OVCAR-4 cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines
Concentration: 10 μM
Incubation Time: 60 min
Result: Showed significantly antiproliferative activities against Leukemia, non-small cell lung cancer, colon cancer, CNS cancer, Melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer cell lines with GI% ranging from 49.1% to 98.46%.

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-468 and OVCAR-4 cancer cell lines, MCF-10A normal breast cancer cell line
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited MDA-MB-468, OVCAR-4 and MCF-10A cells growth with IC50 values of 0.35, 0.29 and 25.9 μM, respectively.

Apoptosis Analysis[1]

Cell Line: OVCAR-4 cell line
Concentration: 0.29 μM
Incubation Time: 24 hours
Result: Induced OVCAR-4 cells apoptosis by increasing the number of early and late apoptosis cells.

Cell Cycle Analysis[1]

Cell Line: OVCAR-4 cell line
Concentration: 0.29 μM
Incubation Time: 24 hours
Result: Arrested cell cycle in the S phase and increased the number of OVCAR-4 cells in pre-G1 phase.
分子量

476.52

Formula

C27H28N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-IN-32874264-13-6VEGFRApoptosisVascular endothelial growth factor receptorpyrazolineSTAT3anticancercell cycleapoptosisMDA-MB-468OVCAR-4ERKphosphorylationInhibitorinhibitorinhibit

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