1. Others Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Calcium Channel P-glycoprotein Cytochrome P450
  3. Verapamil-d3 hydrochloride

Verapamil-d3 hydrochloride  (Synonyms: (±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride)

目录号: HY-A0064S 纯度: 99.57%
COA 产品使用指南

Verapamil-d3 (hydrochloride) 是 Verapamil hydrochloride 的氘代物。Verapamil hydrochloride ((±)-Verapamil hydrochloride) 是一种钙通道 (calcium channel) 阻滞剂,是一种有效的口服活性的第一代 P 糖蛋白 (P-gp) 抑制剂。Verapamil hydrochloride 能也抑制 CYP3A4,并可用于高血压,心律不齐和心绞痛的研究。

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Verapamil-d<sub>3</sub> hydrochloride Chemical Structure

Verapamil-d3 hydrochloride Chemical Structure

CAS No. : 2714485-49-9

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  • 生物活性

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生物活性

Verapamil-d3 (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

494.08

Formula

C27H36D3ClN2O4

CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸维拉帕米 d3 (盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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