1. MAPK/ERK Pathway Stem Cell/Wnt Autophagy
  2. MEK ERK Autophagy
  3. Xantocillin

Xantocillin  (Synonyms: 黄青霉素; Xanthocillin X)

目录号: HY-122404
产品使用指南

Xantocillin (Xanthocillin X) 是从青霉中提取的一种海洋药剂,通过抑制 MEK/ERK 途径诱导自噬。

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Xantocillin Chemical Structure

Xantocillin Chemical Structure

CAS No. : 580-74-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].

体外研究
(In Vitro)

Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1].
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
Incubation Time: 48 hours
Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 24.3 µM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1.
分子量

288.30

Formula

C18H12N2O2

CAS 号
中文名称

黄青霉素

结构分类
初始来源

Marine-Associated Fungus Penicillium sp. ZZ1750

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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