2. Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. Proteasome Apoptosis Parasite
  4. Z-LLY-FMK

Z-LLY-FMK  (Synonyms: Calpain Inhibitor IV)

目录号: HY-136750 纯度: 98.65%
COA 产品使用指南 技术支持

Z-LLY-FMK (Calpain Inhibitor IV) 是一种钙蛋白酶 (calpain) 抑制剂，参与多种细胞系统的凋亡 (apoptosis)。Z-LLY-FMK 抑制胆总管结扎后的肠道凋亡 (apoptosis)。Z-LLY-FMK 减少小鼠感染粗大带绦虫囊尾蚴后的寄生虫负荷。Z-LLY-FMK 可用于囊尾蚴病研究。

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Z-LLY-FMK

Z-LLY-FMK Chemical Structure

CAS No. : 133410-84-1

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规格 价格 是否有货 数量
5 mg ￥2520
In-stock
10 mg ￥4050
In-stock
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50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

Z-LLY-FMK 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3].

IC50 & Target

Calpain[1]
体外研究
(In Vitro)

Z-LLY-FMK (10 μM，预处理 1 小时) 以时间和剂量依赖的方式抑制 Gal-9 诱导的 MOLT-4 细胞凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Z-LLY-FMK 相关抗体:
体内研究
(In Vivo)

Z-LLY-FMK (0.5 mg 通过下腔静脉在胆总管结扎后立即给药，然后第 1-2 天每天两次腹腔注射 0.5 mg，第 3 天上午腹腔注射 0.5 mg) 有效减少胆总管结扎大鼠中的肝细胞凋亡和胆管增生[1]。
Z-LLY-FMK (2.2 μg，腹腔注射，每日一次，从感染前 2 天开始，持续至感染后 30 天) 在 BALB/c 小鼠中感染 10 个粗大带绦虫囊尾蚴后，实现寄生虫负荷减少 80%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) underwent common bile duct ligation (double-ligated with 50 silk and divided between ligatures) to establish a model of extrahepatic cholestasis[1].
Dosage: 0.5 mg
Administration: 0.5 mg via inferior vena cava immediately after common bile duct ligation, then 0.5 mg i.p. twice daily on days 1-2, and 0.5 mg i.p. on the morning of day 3
Result: Significantly diminished hepatocyte apoptosis in common bile duct-ligated rats.
Markedly reduced ductular proliferation in common bile duct-ligated rats.
Animal Model: Taenia crassiceps cysts (10 in 200 µL phosphate-buffered saline) were intraperitoneally challenged into BALB/c mice[2]
Dosage: 2.2 μg
Administration: i.p., daily starting 2 days pre-infection and continuing for 30 days post-challenge
Result: Achieved an 80% reduction in parasite burden in BALB/c mice.
Showed no obvious toxicity.
Caused cysts to exhibit degenerative changes including tegumental erosion, shortened or sloughed microtriches, and breaks in the cyst surface.
Led to an intense but focal inflammatory reaction on cyst surfaces, with presence of fibroblasts, collagen, neutrophils, and macrophages.
分子量

557.65

Formula

C30H40FN3O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (224.15 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7932 mL 8.9662 mL 17.9324 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Z-LLY-FMK 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7932 mL 8.9662 mL 17.9324 mL 44.8310 mL
5 mM 0.3586 mL 1.7932 mL 3.5865 mL 8.9662 mL
10 mM 0.1793 mL 0.8966 mL 1.7932 mL 4.4831 mL
15 mM 0.1195 mL 0.5977 mL 1.1955 mL 2.9887 mL
20 mM 0.0897 mL 0.4483 mL 0.8966 mL 2.2415 mL
25 mM 0.0717 mL 0.3586 mL 0.7173 mL 1.7932 mL
30 mM 0.0598 mL 0.2989 mL 0.5977 mL 1.4944 mL
40 mM 0.0448 mL 0.2242 mL 0.4483 mL 1.1208 mL
50 mM 0.0359 mL 0.1793 mL 0.3586 mL 0.8966 mL
60 mM 0.0299 mL 0.1494 mL 0.2989 mL 0.7472 mL
80 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5604 mL
100 mM 0.0179 mL 0.0897 mL 0.1793 mL 0.4483 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-LLY-FMK133410-84-1Calpain Inhibitor IVProteasomeApoptosisParasiteObstructive jaundiceCalpainInhibitorinhibitorinhibit

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