2. Apoptosis
  3. Apoptosis
  4. 2'-Hydroxyflavanone

2'-Hydroxyflavanone  (Synonyms: 2-羟基黄烷酮)

目录号: HY-134556 纯度: 99.84%
COA 产品使用指南 技术支持

2'-Hydroxyflavanone 是一种黄烷酮，可以抑制癌细胞增殖 (proliferation)、诱导细胞凋亡 (apoptosis) 和减轻炎症。2'-Hydroxyflavanone 对花生四烯酸 (AA) 和 二磷酸腺苷 (ADP) 两种诱导剂引起的血小板聚集 (platelet aggregation) 具有抑制作用，IC50 分别为 47.8 μM 和 147.2 μM。

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2'-Hydroxyflavanone

2'-Hydroxyflavanone Chemical Structure

CAS No. : 17348-76-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥160
In-stock
25 mg ￥100
In-stock
50 mg ￥160
In-stock
100 mg ￥240
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

2'-Hydroxyflavanone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC50s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
4.11 μM
Compound: 1; 2'-HF
Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay
[PMID: 25824662]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse J774A.1 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
[PMID: 25824662]
J774.A1 IC50
71.3 μM
Compound: 1
Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay
[PMID: 25824662]
LNCaP IC50
5.45 μM
Compound: 1; 2'-HF
Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human LNCAP cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
PC-3 IC50
2.56 μM
Compound: 1; 2'-HF
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
[PMID: 30189396]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay
[PMID: 25824662]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 1 hr followed by LPS stimulation for 24 hrs by Griess reagent based assay
[PMID: 25824662]
RAW264.7 IC50
71.3 μM
Compound: 1
Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay
[PMID: 25824662]
分子量

240.25

Formula

C15H12O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

2-羟基黄烷酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (416.23 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1623 mL 20.8117 mL 41.6233 mL
5 mM 0.8325 mL 4.1623 mL 8.3247 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

2'-Hydroxyflavanone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1623 mL 20.8117 mL 41.6233 mL 104.0583 mL
5 mM 0.8325 mL 4.1623 mL 8.3247 mL 20.8117 mL
10 mM 0.4162 mL 2.0812 mL 4.1623 mL 10.4058 mL
15 mM 0.2775 mL 1.3874 mL 2.7749 mL 6.9372 mL
20 mM 0.2081 mL 1.0406 mL 2.0812 mL 5.2029 mL
25 mM 0.1665 mL 0.8325 mL 1.6649 mL 4.1623 mL
30 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4686 mL
40 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6015 mL
50 mM 0.0832 mL 0.4162 mL 0.8325 mL 2.0812 mL
60 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.7343 mL
80 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0406 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Hydroxyflavanone17348-76-42-羟基黄烷酮Apoptosisarachidonic acidaenosine diphosphateplatelet aggregationInhibitorinhibitorinhibit

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