1. Others Cell Cycle/DNA Damage Cytoskeleton Immunology/Inflammation NF-κB Apoptosis Autophagy Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite
  3. 2-Methoxyestradiol-13C6

2-Methoxyestradiol-13C6  (Synonyms: 二甲氧基雌二醇-13C6; 2-ME2-13C6; NSC-659853-13C6)

目录号: HY-12033S1
产品使用指南

2-Methoxyestradiol-13C6 是一种 13C 标记的 2-Methoxyestradiol。2-Methoxyestradiol (2-ME2),具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物,是凋亡 (apoptosis) 诱导剂和血管生成 (angiogenesis) 抑制剂,具有有效的抗肿瘤活性。2-Methoxyestradiol 也可破坏微管 (microtubules) 的稳定。2-Methoxyestradiol 是一种有效的超氧化物歧化酶 (SOD) 抑制剂和活性氧生成剂,可诱导转化细胞系 HEK293、癌细胞系 U87 和 HeLa 的自噬 (autophagy)。

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2-Methoxyestradiol-<sup>13</sup>C<sub>6</sub> Chemical Structure

2-Methoxyestradiol-13C6 Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Methoxyestradiol-13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

308.36

Formula

C1313C6H26O3

中文名称

二甲氧基雌二醇-13C6; 二甲氧雌二醇-13C6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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